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Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

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dc.creatorGoetz, Michael A.
dc.creatorHensens, Otto D.
dc.creatorZink, Deborah L.
dc.creatorBorris, Robert P.
dc.creatorMorales Quirós, Juan Francisco
dc.creatorTamayo Castillo, Giselle
dc.creatorSlaughter, Robert S.
dc.creatorFelix, John P.
dc.creatorBall, Richard G.
dc.date.accessioned2022-12-01T21:28:39Z
dc.date.available2022-12-01T21:28:39Z
dc.date.issued1998
dc.description.abstractThe isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. The first potent and selective small molecule blockers of KV 1.3, cprreolide (1) and its dehydro derivative 2 have been identified from extracts of Spachea correoe. Agents that inhibit the opening of this voltage-gated potassium channel can be expected to have immunosuppressive properties.es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.description.sponsorshipInstituto Nacional de Biodiversidad//INBio/Costa Ricaes_ES
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0040403998004274#!es_ES
dc.identifier.doi10.1016/S0040-4039(98)00427-4
dc.identifier.issn0040-4039
dc.identifier.urihttps://hdl.handle.net/10669/87847
dc.language.isoenges_ES
dc.rightsacceso embargado
dc.sourceTetrahedron Letters; Vol. 39 Núm. 19: 1998 pp. 2895-2898es_ES
dc.subjectKv1.3 channel blockers correolide and dehydrocorreolidees_ES
dc.subjectIsolation and structurees_ES
dc.subject2D NMRes_ES
dc.subjectHMBCes_ES
dc.subjectEI-MSes_ES
dc.subjectX-rayes_ES
dc.titlePotent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correaees_ES
dc.typeartículo originales_ES

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