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Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

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dc.creatorMike, Laura A.
dc.creatorTripathi, Ashootosh
dc.creatorBlankenship, Connor M.
dc.creatorSaluk, Alyssa
dc.creatorSchultz, Pamela J.
dc.creatorTamayo Castillo, Giselle
dc.creatorSherman, David H.
dc.creatorMobley, Harry L. T.
dc.date.accessioned2020-02-20T15:36:22Z
dc.date.available2020-02-20T15:36:22Z
dc.date.issued2017
dc.description.abstractHigh-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.identifier.citationhttps://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07732g#!divAbstract
dc.identifier.doi10.1039/c7cc07732g
dc.identifier.issn1364-548X
dc.identifier.pmid29139494
dc.identifier.pmidPMC5706644
dc.identifier.urihttps://hdl.handle.net/10669/80612
dc.language.isoen_USes_ES
dc.rightsacceso embargado
dc.sourceChemical Communications, vol.53(95), pp.12778-12781es_ES
dc.subjectNicoyamycin Aes_ES
dc.subjectEscherichia colies_ES
dc.subjectInhibitores_ES
dc.subjectAntibioticses_ES
dc.subjectBacterial infectionses_ES
dc.titleDiscovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environmentses_ES
dc.typeartículo original

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