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Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum

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dc.creatorGutiérrez, José María
dc.creatorRojas Céspedes, Gustavo
dc.creatorLomonte, Bruno
dc.creatorGené, José Antonio
dc.creatorCerdas Fallas, Luis
dc.date.accessioned2017-06-06T21:03:52Z
dc.date.available2017-06-06T21:03:52Z
dc.date.issued1987
dc.description.abstractThe myotoxin from B. asper snake venom inhibited Ca-ATPase activity of rabbit sarcoplasmic reticulum after incubation in vitro. Inhibition was non-competitive and albumin enhanced the effect of the toxin. Furthermore, B. asper myotoxin hydrolyzed sarcoplasmic reticulum phospholipids and induced a dose-dependent release of horseradish peroxidase that had been trapped in sarcoplasmic reticulum vesicles. Binding studies indicated that myotoxin does not bind to any particular protein of this membrane, suggesting that the toxin might interact with phospholipids. Inhibition of Ca-ATPase is probably a consequence of an alteration in sarcoplasmic reticulum phospholipids.es
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es
dc.description.sponsorshipUniversidad de Costa Rica/[Vi-741-84-085]/UCR/Costa Ricaes
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010187901449
dc.identifier.doihttps://doi.org/10.1016/0041-0101(87)90144-9
dc.identifier.issn0041-0101
dc.identifier.pmid2963409
dc.identifier.urihttps://hdl.handle.net/10669/29948
dc.language.isoen_US
dc.rightsacceso embargado
dc.sourceToxicon; Volumen 25, Número 11. 1987es
dc.subjectMyotoxines
dc.subjectBothrops asperes
dc.subjectVenomes
dc.subjectSnake venomes
dc.titleEffects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulumes
dc.typeartículo original

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