Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.
Fecha
2023
Tipo
artículo original
Autores
Dec, Eric
Clement, James
Cheng, Kaiyang
Church, George M.
Fossel, Michael B.
Rehkopf, David H.
Rosero Bixby, Luis
Kobor, Michael S.
Lin, David TS.
Lu, Ake T.
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Resumen
Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome- wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.
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GENES, MORTALITY