Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats




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Silva Carvalho, Rosimeire
Gaspar, Matheus Z.
Quadros, Luiz H. B.
Lobo, Luís G. G.
Giuffrida, Rogério
Santarém, Cecília L.
Silva, Elisangela O.
Gerez, Juliana Rubira
Silva, Nelson J.
Hyslop, Stephen

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In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations


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Micrurus, varespladib, SUSTANCIA PELIGROSA, Snake venom