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Proteoform-resolved quantitative venomics: looking through a crystal ball

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dc.creatorCalvete Chornet, Juan José
dc.creatorPetras, Daniel
dc.creatorCalderón Celis, Francisco
dc.creatorLomonte, Bruno
dc.creatorRuiz Encinar, Jorge
dc.creatorSanz Medel, Alfredo
dc.date.accessioned2018-06-01T15:04:08Z
dc.date.available2018-06-01T15:04:08Z
dc.date.issued2017-04
dc.description.abstractIn this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflectses_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad/[BFU2013-42833-P]//Españaes_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad/[BES-2014-068032]//Españaes_ES
dc.identifier.citationhttps://jvat.biomedcentral.com/articles/10.1186/s40409-017-0116-9
dc.identifier.doi10.1186/s40409-017-0116-9
dc.identifier.issn1678-9199
dc.identifier.pmid28465678
dc.identifier.pmidPMC5408492
dc.identifier.urihttps://hdl.handle.net/10669/74787
dc.language.isoen_USes_ES
dc.rightsacceso abierto
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceJournal of Venomous Animals and Toxins including Tropical Diseases, Vol 23(27)es_ES
dc.subjectTop-down proteomicses_ES
dc.subjectTop-down venomicses_ES
dc.subjectProtein species resolved venomices_ES
dc.subjectAbsolute quantificationes_ES
dc.subjectInductively coupled plasma mass spectrometryes_ES
dc.subjectSnake venomes_ES
dc.titleProteoform-resolved quantitative venomics: looking through a crystal balles_ES
dc.typeartículo original

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