Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom

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dc.creatorGutiérrez, José María
dc.creatorChaves Mora, Fernando
dc.creatorCerdas Fallas, Luis
dc.date.accessioned2016-11-04T19:45:31Z
dc.date.available2016-11-04T19:45:31Z
dc.date.issued1986
dc.description.abstractThe time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied. The venom induced myonecrosis, and a prominent decrease in muscle levels of creatine kinase (CK) as early as 3 hr after envenomation. Inflammatory infiltrate was scarce by 6 hr. but increased markedly at 24, 48 and 72 hr. Samples of infiltrate obtained at 6 and 24 hr contained polymorphonuclear leucocytes as the predominant cell type, whereas at 48 hr and 72 hr the relative number of macrophages increased. Inflammatory cells were located within necrotic muscle cells, as well as in the interstitial space, but there were some necrotic areas devoid of inflammatory cells even one week after envenomation. When correlating the presence of inflammatory cells with degradation of myofibrillar proteins, it was observed that at 6 hr there was little muscle protein degradation. By 48 hr a decrease in "non collagen" proteins was observed, together with a reduction in some myofibrillar components, as judged by electrophoresis. Proteolytic enzymes of inflammatory cells may play an important role in myofibrillar protein degradation after myonecrosis induced by B. asper venom.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.doi10.15517/rbt.v34i2.24233es_ES
dc.identifier.issn2215-2075
dc.identifier.urihttps://hdl.handle.net/10669/29146
dc.language.isoen_USes_ES
dc.rightsacceso abierto
dc.sourceRevista de Biología Tropical, Volumen 34, Número 2, 1986es_ES
dc.subjectAnimalses_ES
dc.subjectNecrosises_ES
dc.subjectMuscle Proteinses_ES
dc.subjectElectrophoresis, Polyacrylamide Geles_ES
dc.subjectCreatine Kinasees_ES
dc.subjectCrotalid Venomses_ES
dc.subjectMyositises_ES
dc.subjectSnake venomes_ES
dc.titleInflammatory infiltrate in skeletal muscle injected with Bothrops asper venomes_ES
dc.typeartículo original

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Biología
Revista de Biología Tropical Vol.34 (2)