Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC
| dc.creator | Sáenz Castillo, Antonio | |
| dc.creator | Sanabria Chinchilla, Jean | |
| dc.creator | García Piñeres, Alfonso J. | |
| dc.creator | Tamayo Castillo, Giselle | |
| dc.date.accessioned | 2022-07-21T16:59:00Z | |
| dc.date.available | 2022-07-21T16:59:00Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined in an LPS stimulated RAW 264.7 murine macrophage assay with IC50 values for inhibition of NO production of (18 ± 3) and (26 ± 5) μM, for 1 and 2, respectively. These compounds do not inhibit NO production by a competitive inhibition of the iNOS enzyme and show anti-inflammatory properties by lowering the expression of pro-inflammatory genes (TNF-α, IL-1β, CXCL2 and CCL2), as determined by qRT-PCR. Electrochemical measurements using cyclic voltammetry (CV) show that compound 1 exhibits anti-oxidant properties. This is the first phytochemical study of this plant, and we report a preliminary study of the biological activity of the isolated compounds. | es |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA) | es |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) | es |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Electroquímica y Energía Química (CELEQ) | es |
| dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química | es |
| dc.description.sponsorship | Universidad de Costa Rica/[809-C0-073]/UCR/Costa Rica | es |
| dc.identifier.citation | https://www.sciencedirect.com/science/article/pii/S1874390021002421?via%3Dihub | |
| dc.identifier.codproyecto | 809-C0073 | |
| dc.identifier.doi | https://doi.org/10.1016/j.phytol.2021.10.018 | |
| dc.identifier.issn | 1874-3900 | |
| dc.identifier.uri | https://hdl.handle.net/10669/86998 | |
| dc.language.iso | eng | |
| dc.rights | acceso embargado | |
| dc.source | Phytochemistry Letters, vol.47, pp.28-33. | es |
| dc.subject | Piper garagaranum C. DC. | es |
| dc.subject | Anti-inflammatory | es |
| dc.subject | Citotoxicity | es |
| dc.subject | Gene expression | es |
| dc.subject | Bio-assay guided fractionation | es |
| dc.subject | Prenylated hydroxybenzoic acid | es |
| dc.title | Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC | es |
| dc.type | artículo original | es |