Hypoglycaemic, hypolipidaemic and antioxidant effects of blackberry beverage consumption in streptozotocin-induced diabetic rats

dc.creatorAzofeifa Cordero, Gabriela
dc.creatorQuesada Mora, Silvia
dc.creatorNavarro Bolaños, Laura
dc.creatorHidalgo Muñoz, Olman
dc.creatorPortet, Karine
dc.creatorPérez Carvajal, Ana Mercedes
dc.creatorVaillant Barka, Fabrice
dc.creatorPoucheret, Patrick
dc.creatorMichel, Alain
dc.date.accessioned2017-09-06T21:45:29Z
dc.date.available2017-09-06T21:45:29Z
dc.date.issued2016
dc.description.abstractAbnormal glucose metabolism, hyperlipidaemia profiles and high levels of radical oxygen species (ROS) are classic features of diabetes. This study evaluates the effect of the consumption of two different blackberry beverages at 25 and 12.5% given orally for 40 days to rats with streptozotocin induced diabetes. The lower dose of blackberry (12.5%) non-statistically decreased glycaemia (−10.4%), triacylglycerols (−4.6%) and cholesterol (−21.0%). These differences were not statistically significant. The higher dose of blackberry (25%) significantly decreased glucose (−48.6%), triacylglycerols (−43.5%) and cholesterol (−28.6%). The higher dose of blackberry (25%) improved plasma antioxidant capacity, reduced the levels of lipid peroxidation in plasma (−19%) and in kidney (−23%). Blackberry intake did not improve catalase, suggesting that attenuation of oxidative stress via scavenging activities rather than improving the activities of antioxidant enzymes. These results provide promising data for this blackberry as a dietary adjuvant to the pharmacological management of diabetes.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro Nacional de Ciencia y Tecnología de Alimentos (CITA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicina
dc.description.sponsorshipConsejo Nacional de Rectores/[801-B1-655]/CONARE/Costa Ricaes_ES
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S1756464616302158?via%3Dihub
dc.identifier.doi10.1016/j.jff.2016.08.007
dc.identifier.issn1756-4646
dc.identifier.urihttps://hdl.handle.net/10669/73134
dc.language.isoen_USes_ES
dc.rightsacceso abierto
dc.sourceJournal of Functional Foods, Volumen 26. 2016es_ES
dc.subjectBlackberry juicees_ES
dc.subjectRubus adenotrichoses_ES
dc.subjectDiabetes mellituses_ES
dc.subjectDyslipidaemiaes_ES
dc.subjectPlasma antioxidant capacityes_ES
dc.subjectLipid peroxidationes_ES
dc.titleHypoglycaemic, hypolipidaemic and antioxidant effects of blackberry beverage consumption in streptozotocin-induced diabetic ratses_ES
dc.typeartículo original

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