One-Pot Conversion of Aldehydes and Ketones into 1-Substituted and 1,4-Disubstituted 1,3-Enynes

dc.creator	Cabezas Pizarro, Jorge A.
dc.creator	Poveda Rojas, Rebeca
dc.creator	Brenes Jiménez, José Ángel
dc.date.accessioned	2023-03-17T21:26:01Z
dc.date.available	2023-03-17T21:26:01Z
dc.date.issued	2018
dc.identifier.citation	https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610197	es_ES
dc.identifier.issn	0039-7881
dc.identifier.uri	https://hdl.handle.net/10669/88358
dc.description.abstract	Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generates the operational equivalent of 1,3-dilithiopropyne, which upon treatment with aldehydes or ketones, produces the corresponding alkoxy lithium acetylide intermediates. Reaction of this alkoxide with tosyl chloride, and t-BuLi produces 1-substituted, or 1,1-disubstituted 1,3-enynes in a one-pot reaction. When this lithium acetylide intermediates, obtained by this procedure, were used to perform palladium-catalyzed cross-coupling reactions, followed by addition of thionyl chloride and pyridine, 1,4-disubstituted or 1,1,4-trisubstituted 1,3-enynes were obtained in a one-pot protocol.	es_ES
dc.language.iso	eng	es_ES
dc.source	Synthesis, vol.50(17), pp.3307-3321	es_ES
dc.subject	CHEMISTRY	es_ES
dc.title	One-Pot Conversion of Aldehydes and Ketones into 1-Substituted and 1,4-Disubstituted 1,3-Enynes	es_ES
dc.type	artículo original	es_ES
dc.identifier.doi	10.1055/s-0037-1610197
dc.description.procedence	UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química	es_ES