Mostrar el registro sencillo del ítem

Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

dc.creatorWipf, Peter
dc.creatorLynch, Stephen M.
dc.creatorBirmingham, Anne
dc.creatorTamayo Castillo, Giselle
dc.creatorJiménez Ardón, Allan Miguel
dc.creatorCampos, Nefertiti
dc.creatorPowis, Garth
dc.date.accessioned2022-10-13T21:51:19Z
dc.date.available2022-10-13T21:51:19Z
dc.date.issued2004
dc.identifier.citationhttps://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5Des_ES
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.urihttps://hdl.handle.net/10669/87509
dc.description.abstractSpiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM.es_ES
dc.description.sponsorshipNational Institutes of Health/[U19CA-52995]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Aeronautics and Space Administration/[NAG 13171]/NASA/Estados Unidoses_ES
dc.language.isoenges_ES
dc.sourceOrganic & Biomolecular Chemistry, vol.2 (11), pp.1651-1658.es_ES
dc.subjectThioredoxines_ES
dc.subjectNatural productses_ES
dc.subjectInhibitorses_ES
dc.titleNatural product based inhibitors of the thioredoxin-thioredoxin reductase systemes_ES
dc.typeartículo originales_ES
dc.identifier.doi10.1039/b402431a
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES


Ficheros en el ítem

Thumbnail
Nombre:
29-Org. Biomol. Chem. 2004 Wipf.pdf
Tamaño:
205.5Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem