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dc.creatorRamírez Morales, Didier
dc.creatorMasís Mora, Mario Alberto
dc.creatorMontiel Mora, José R.
dc.creatorCambronero Heinrichs, Juan Carlos
dc.creatorPérez Rojas, Greivin
dc.creatorTormo Budowski, Rebeca
dc.creatorMéndez Rivera, Michael
dc.creatorBriceño Guevara, Susana
dc.creatorGutiérrez Quirós, Juan Antonio
dc.creatorArias Mora, Víctor
dc.creatorBrenes Alfaro, Laura
dc.creatorBeita Sandí, Wilson
dc.creatorRodríguez Rodríguez, Carlos E.
dc.date.accessioned2021-10-01T16:46:07Z
dc.date.available2021-10-01T16:46:07Z
dc.date.issued2021
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0957582021003876
dc.identifier.issn0957-5820
dc.identifier.urihttps://hdl.handle.net/10669/84483
dc.description.abstractThe occurrence of pharmaceuticals in surface water has been barely studied in Latin America. This work aimed to i) develop a multi-residue liquid chromatography- triple quadrupole mass spectrometry (LC–MS/MS) method for the determination of pharmaceutical active compounds (PhACs); ii) monitor 70 PhACs in three urban-influenced rivers in San José, Costa Rica; and iii) perform the risk assessment of detected compounds and ecotoxicological evaluation on water samples. Caffeine, 1,7-dimethylxanthine, naproxen, gemfibrozil and ibuprofen were the most frequent among 23 detected compounds. Concentrations ranged from 0.013 μg/L to 53.8 μg/L (62 % detections between 0.1 μg/L–1 μg/L), and the highest values corresponded to caffeine, 1,7-dimethylxanthine, ofloxacin, gemfibrozil and cephalexin. The environmental risk estimated using the hazard quotient (HQ) approach, revealed four and eleven compounds with medium and high risk, respectively. The highest risk (HQ >10) was determined for diphenhydramine, risperidone, fluoxetine, trimethoprim, ofloxacin and azithromycin; nonetheless, high risk (HQ >1) was also estimated for caffeine, diclofenac, clarithromycin, gemfibrozil and ibuprofen. Total HQ sample values (ΣHQ), calculated as the sum of individual HQs for each detected compound, revealed the highest hazard in surface water near wastewater treatment plant discharges, followed by the locations of higher urban influence (in the Virilla river). Ecotoxicological evaluation showed no acute toxicity towards Daphnia magna and Vibrio fischeri in surface water samples; on the contrary, toxicity towards Lactuca sativa (germination tests) showed a similar pattern to that determined with the ΣHQ, although the highest toxicity was observed downstream with respect to the urban influence of the metropolitan area. These findings help to visualize the importance of pharmaceutical residues in the overall toxicity of surface water samples, and remark the relevance of monitoring these compounds, as an input for the implementation of future mitigation actions.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-B7-A09]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-B8-510]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-B8-144]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[802-B8-145]/UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Ciencia, Tecnología y Telecomunicaciones/[FI-197B-17]/MICITT/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Ciencia, Tecnología y Telecomunicaciones/[FI-056B-17]/MICITT/Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceProcess Safety and Environmental Protection, vol.153, pp.289-300es_ES
dc.subjectAnalytical validationes_ES
dc.subjectEcotoxicityes_ES
dc.subjectHazard quotientes_ES
dc.subjectAnthropogenic pollutiones_ES
dc.subjectEnvironmental riskes_ES
dc.subjectPharmaceuticalses_ES
dc.titleMulti-residue analysis of pharmaceuticals in water samples by liquid chromatography- mass spectrometry: Quality assessment and application to the risk assessment of urban-influenced surface waters in a metropolitan area of Central Americaes_ES
dc.typeartículo científico
dc.identifier.doi10.1016/j.psep.2021.07.025
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro en Investigación en Contaminación Ambiental (CICA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES
dc.identifier.codproyecto802-B7-A09
dc.identifier.codproyecto802-B8-510
dc.identifier.codproyecto802-B8-144
dc.identifier.codproyecto802-B8-145


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