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dc.creatorCalvete Chornet, Juan José
dc.creatorLomonte, Bruno
dc.creatorSaviola, Anthony J.
dc.creatorBonilla Murillo, Fabián
dc.creatorSasa Marín, Mahmood
dc.creatorWilliams, David J.
dc.creatorUndheim, Eivind Andreas Baste
dc.creatorSunagar, Kartik
dc.creatorJackson, Timothy N. W.
dc.date.accessioned2021-06-24T21:22:31Z
dc.date.available2021-06-24T21:22:31Z
dc.date.issued2021-07
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S2590171021000060?via%3Dihubes_ES
dc.identifier.issn2590-1710
dc.identifier.urihttps://hdl.handle.net/10669/83788
dc.description.abstractSnakebite envenoming is a neglected tropical disease that may claim over 100,000 human lives annually worldwide. Snakebite occurs as the result of an interaction between a human and a snake that elicits either a defensive response from the snake or, more rarely, a feeding response as the result of mistaken identity. Snakebite envenoming is therefore a biological and, more specifically, an ecological problem. Snake venom itself is often described as a “cocktail”, as it is a heterogenous mixture of molecules including the toxins (which are typically proteinaceous) responsible for the pathophysiological consequences of envenoming. The primary function of venom in snake ecology is pre-subjugation, with defensive deployment of the secretion typically considered a secondary function. The particular composition of any given venom cocktail is shaped by evolutionary forces that include phylogenetic constraints associated with the snake’s lineage and adaptive responses to the snake’s ecological context, including the taxa it preys upon and by which it is predated upon. In the present article, we describe how conceptual frameworks from ecology and evolutionary biology can enter into a mutually enlightening relationship with clinical toxinology by enabling the consideration of snakebite envenoming from an “ecological stance”. We detail the insights that may emerge from such a perspective and highlight the ways in which the high-fidelity descriptive knowledge emerging from applications of -omics era technologies – “venomics” and “antivenomics” – can combine with evolutionary explanations to deliver a detailed understanding of this multifactorial health crisis.es_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovacion/[BMC 2004-01432]//Españaes_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovacion/[BFU 2007-61563]//Españaes_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovacion/[BFU 2010-173730]//Españaes_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovacion/[BFU 2013-42833-P]//Españaes_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovacion/[BFU 2017-89103-P]//Españaes_ES
dc.description.sponsorshipNorwegian Research Council/[No.287462.]/NFR/Noruegaes_ES
dc.description.sponsorshipNational Health and Medical Research Council/[Grant 13/093/002 AVRU]/Australiaes_ES
dc.description.sponsorshipDBT/Wellcome Trust India Alliance/[IA/I/19/2/504647]//Indiaes_ES
dc.language.isoenges_ES
dc.sourceToxicon: X, vol.9-10, pp.1-16es_ES
dc.subjectSnakees_ES
dc.subjectVenomicses_ES
dc.subjectProteomicses_ES
dc.subjectToxinologyes_ES
dc.titleMutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stancees_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.toxcx.2021.100070
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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