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Iodine Quantification to Distinguish Clear Cell from Papillary Renal Cell Carcinoma at Dual-Energy Multidetector CT: A Multireader Diagnostic Performance Study
dc.creator | Mileto, Achille | |
dc.creator | Marin, Daniele | |
dc.creator | Alfaro Córdoba, Marcela | |
dc.creator | Ramirez Giraldo, Juan Carlos | |
dc.creator | Eusemann, Christian D. | |
dc.creator | Scribano, Emanuele | |
dc.creator | Blandino, Alfredo | |
dc.creator | Mazziotti, Silvio | |
dc.creator | Ascenti, Giorgio | |
dc.date.accessioned | 2018-06-11T19:18:14Z | |
dc.date.available | 2018-06-11T19:18:14Z | |
dc.date.issued | 2014-08 | |
dc.identifier.citation | https://pubs.rsna.org/doi/10.1148/radiol.14140171 | |
dc.identifier.issn | 0033-8419 | |
dc.identifier.issn | 1527-1315 | |
dc.identifier.uri | https://hdl.handle.net/10669/74886 | |
dc.description.abstract | Purpose: to investigate whether dual-energy multidetector row computed tomographic (CT) imaging with iodine quantification is able to distinguish between clear cell and papillary renal cell carcinoma (RCC) subtypes. Materials and Methods: in this retrospective, HIPAA-compliant, institutional review board–approved study, 88 patients (57 men, 31 women) with diagnosis of either clear cell or papillary RCC at pathologic analysis, who underwent contrast material–enhanced dual-energy nephrographic phase study between December 2007 and June 2013, were included. Five readers, blinded to pathologic diagnosis, independently evaluated all cases by determining the lesion iodine concentration on color-coded iodine maps. The receiving operating characteristic curve analysis was adopted to estimate the optimal threshold for discriminating between clear cell and papillary RCC, and results were validated by using a leave-one-out cross-validation. Interobserver agreement was assessed by using an intraclass correlation coefficient. The correlation between tumor iodine concentration and tumor grade was investigated. Results: a tumor iodine concentration of 0.9 mg/mL represented the optimal threshold to discriminate between clear cell and papillary RCC, and it yielded the following: sensitivity, 98.2% (987 of 1005 [95% confidence interval: 97.7%, 98.7%]); specificity, 86.3% (272 of 315 [95% confidence interval: 85.0%, 87.7%]); positive predictive value, 95.8% (987 of 1030 [95% confidence interval: 95.0%, 96.6%]); negative predictive value, 93.7% (272 of 290 [95% confidence interval: 92.8%, 94.7%]); overall accuracy of 95.3% (1259 of 1320 [95% confidence interval: 94.6%, 96.2%]), with an area under the curve of 0.923 (95% confidence interval: 0.913, 0.933). An excellent agreement was found among the five readers in measured tumor iodine concentration (intraclass correlation coefficient, 0.9990 [95% confidence interval: 0. 9987, 0.9993). A significant correlation was found between tumor iodine concentration and tumor grade for both clear cell (τ = 0.85; P < .001) and papillary RCC (τ = 0.53; P < .001). Conclusion: dual-energy multidetector CT with iodine quantification can be used to distinguish between clear cell and papillary RCC, and it provides insights regarding the tumor grade. | es_ES |
dc.language.iso | en_US | es_ES |
dc.relation.ispartof | Radiology Volumen 273 Número 3 | |
dc.source | Radiology, Vol 273(3), p.813-820 | es_ES |
dc.subject | Renal mass | es_ES |
dc.subject | Dual energy CT | es_ES |
dc.subject | Renal cell carcinoma | es_ES |
dc.subject | Surgery | es_ES |
dc.subject | Partial nephrectomy | es_ES |
dc.subject | Total nephrectomy | es_ES |
dc.subject | Pathology | es_ES |
dc.subject | Clear cell renal cell carcinoma | es_ES |
dc.subject | Papillary renal cell carcinoma | es_ES |
dc.subject | 616.075 72 Iodine quantification to distinguish clear cell from papillary renal cell carcinoma at dual-energy multidetector CT: a multireader diagnostic performance study | es_ES |
dc.title | Iodine Quantification to Distinguish Clear Cell from Papillary Renal Cell Carcinoma at Dual-Energy Multidetector CT: A Multireader Diagnostic Performance Study | es_ES |
dc.type | artículo original | |
dc.date.updated | 2018-05-14T20:27:21Z | |
dc.identifier.doi | 10.1148/radiol.14140171 | |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Sociales::Facultad de Ciencias Económicas::Escuela de Estadística | es_ES |
dc.identifier.pmid | 25162309 |
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