Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia
artículo original

Date
2014-11-05Author
Herrera Vega, María
Paiva, Owen K.
Pagotto, Ana Helena
Segura Ruiz, Álvaro
Serrano, Solange M. T.
Vargas Arroyo, Mariángela
Villalta Arrieta, Mauren
Jensen, Simon D.
León Montero, Guillermo
Williams, David J.
Gutiérrez, José María
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Show full item recordAbstract
Antivenoms manufactured by bioCSL Limited (Australia) and Instituto Clodomiro Picado (Costa Rica) against the venom of the taipan snakes (Oxyuranus scutellatus) from Australia and Papua New Guinea (PNG), respectively, were compared using antivenomics, an analytical approach that combines proteomics with immunoaffinity chromatography. Both antivenoms recognized all venom proteins present in venom from PNG O. scutellatus, although a pattern of partial recognition was observed for some components. In the case of the Australian O. scutellatus venom, both antivenoms immunorecognized the majority of the components, but the CSL antivenom showed a stronger pattern of immunoreactivity, which was revealed by the percentage of retained proteins in the immunoaffinity column. Antivenoms interacted with taipoxin in surface plasmon resonance. These observations on antivenomics agree with previous neutralization studies.
External link to the item
10.4269/ajtmh.14-0333Collections
- Microbiología [1105]