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dc.creatorHarhay, Meera N.
dc.creatorHarhay, Michael O.
dc.creatorCoto Yglesias, Fernando
dc.creatorRosero Bixby, Luis
dc.date.accessioned2016-12-06T20:57:21Z
dc.date.available2016-12-06T20:57:21Z
dc.date.issued2016-01
dc.identifier.citationhttp://onlinelibrary.wiley.com/doi/10.1111/tmi.12622/full
dc.identifier.issn1365-3156
dc.identifier.urihttps://hdl.handle.net/10669/29358
dc.description.abstractObjectives Recent studies in Central America indicate that mortality attributable to chronic kidney disease (CKD) is rising rapidly. We sought to determine the prevalence and regional variation of CKD and the relationship of biologic and socio-economic factors to CKD risk in the older-adult population of Costa Rica. Methods We used data from the Costa Rican Longevity and Health Aging Study (CRELES). The cohort was comprised of 2657 adults born before 1946 in Costa Rica, chosen through a sampling algorithm to represent the national population of Costa Ricans >60 years of age. Participants answered questionnaire data and completed laboratory testing. The primary outcome of this study was CKD, defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2. Results The estimated prevalence of CKD for older Costa Ricans was 20% (95% CI 18.5–21.9%). In multivariable logistic regression, older age (adjusted odds ratio [aOR] 1.08 per year, 95% CI 1.07–1.10, P < 0.001) was independently associated with CKD. For every 200 m above sea level of residence, subjects' odds of CKD increased 26% (aOR 1.26 95% CI 1.15–1.38, P < 0.001). There was large regional variation in adjusted CKD prevalence, highest in Limon (40%, 95% CI 30–50%) and Guanacaste (36%, 95% CI 26–46%) provinces. Regional and altitude effects remained robust after adjustment for socio-economic status. Conclusions We observed large regional and altitude-related variations in CKD prevalence in Costa Rica, not explained by the distribution of traditional CKD risk factors. More studies are needed to explore the potential association of geographic and environmental exposures with the risk of CKD.es_ES
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases of the United States National Institutes of Health/[K23-DK105207-01]//Estados Unidoses_ES
dc.description.sponsorshipWellcome Trust///Estados Unidoses_ES
dc.description.sponsorshipNational Heart, Lung And Blood Institute///Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceTropical Medicine & International Health; Volumen 21, Número 1. 2016es_ES
dc.subjectAltitudees_ES
dc.subjectChronic Kidney Diseasees_ES
dc.subjectMesoamerican Nephropathyes_ES
dc.subjectCosta Ricaes_ES
dc.subjectEpidemiologyes_ES
dc.subjectTropical Chronic Diseasees_ES
dc.titleAltitude and regional gradients in chronic kidney disease prevalence in Costa Rica: Data from the Costa Rican Longevity and Healthy Aging Studyes_ES
dc.typeartículo científico
dc.identifier.doi10.1111/tmi.12622
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES


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