Abstract : A survey was conducted of medicinal plants for gastrointestinal disorders used by inhabitants of the Central Valley in Costa Rica by means of interviews with medicinal plant vendors of the central markets of the ...

Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group ...

Recombinant DNA technologies enable the direct isolation and expression of novel genes from biotopes containing complex consortia of uncultured microorganisms. In this study, genomic libraries were constructed from microbial ...

Fourteen novel sesquiterpene lactones of the germacranolide type have been isolated from the aerial parts of Mikania guaco: six costunolide, two melampolide and six germacra-4-trans,10(14),11(13)-trien-12,6α-olide derivatives. ...

Bioprospecting is defined as the systematic search for genes, compounds, designs, and organisms that might have a potential economic use and might lead to a product development. In 1991, Costa Rica's National Institute of ...

Siderophores are high-affinity iron chelators produced by microorganisms and frequently contribute to the virulence of human pathogens. Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus ...

The aerial parts of Clibadium pittierii afforded in addition to known melampolides two new ones, one being esterified with a homoditerpenic acid and the homoditerpenic acid itself. The structures were elucidated by high ...

Targeting and inhibiting CMG2 (Capillary Morphogenesis Gene protein 2) represents a new strategy for therapeutic agents for cancer and retinal diseases due to CMG2’s role in blood vessel growth (angiogenesis). A high ...

Inhibitors of transcriptional protein–protein interactions (PPIs) have high value both as tools and for therapeutic applications. The PPI network mediated by the transcriptional coactivator Med25, for example, regulates ...

The aerial parts of Chromolaena connivens afforded in addition to widespread compounds four ent-clerodane derivatives and two epimeric prostaglandin-like acids. A second species, C. turnariensis, only gave widespread ...