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Membrane-damaging and cytotoxic sphingomyelinases and phospholipases

Flores Díaz, Marietta; Monturiol Gross, Laura; Alape Girón, Alberto (2015-06-05)

This chapter presents an overview of the classification, structure, and main physiopathological activities of bacterial sphingomyelinases and phospholipases, providing examples of their roles as virulence factors in several ...

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

Gutiérrez, José María; Lomonte, Bruno; León Montero, Guillermo; Alape Girón, Alberto; Flores Díaz, Marietta; Sanz, Libia; Angulo Ugalde, Yamileth; Calvete Chornet, Juan José (2009-03-06)

Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and ...

High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

Moreira Soto, Andrés; Gutiérrez, José María; Alape Girón, Alberto; Drexler, Jan Felix; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Macaya Hayes, Román; Kühne, Arne; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Reusken, Chantal B. E. M.; Drosten, Christian (2021)

SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) ...

Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19

Alape Girón, Alberto; Moreira Soto, Andrés; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Herrera Vega, María; León Montero, Guillermo; Macaya Hayes, Román; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Narayanan, Aarthi; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Drexler, Jan Felix; Gutiérrez, José María (2021-09)

The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ...