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Dengue Virus Infection of Primary Human Smooth Muscle Cells
(2018-11-05)
Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components ...
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Bioinformatics advances in Costa Rica: Retrospective view and perspectives
(2021-11-09)
Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ...
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
(2018)
Cancer is a group of heterogeneous and complex
diseases, with limited therapeutic options due to the recurrent
emergence of drug resistance. Sphingolipids are bioactive
molecules that participate in signaling of cell ...
Development and validation of fluorescence live-cell imaging approaches to study flavivirus infection kinetics in animal cells
(2021-10-07)
The genus Flavivirus in the family Flaviviridae comprises many clinically important viruses,
such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV). The quest for
therapeutic targets to combat ...
Transcriptomic determinants of the response of ST-111 Pseudomonas aeruginosa AG1 to ciprofloxacin identified by a top-down systems biology approach
(2020)
Pseudomonas aeruginosa is an opportunistic pathogen that thrives in diverse environments and causes a variety of human infections. Pseudomonas aeruginosa AG1 (PaeAG1) is a high-risk sequence type 111 (ST-111) strain isolated ...
Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells
(2021-09-18)
In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely
used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having
low responses with an ...
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
(2017)
Sphingolipid (SL) signaling pathway is a complex
biological system able to integrate different types of cellular
stress signals related to induction of cell death pathways with
special interest in cancer. This makes of ...
A Fluorescent Real-Time Plaque Assay Enables Single-Cell Analysis of Virus-Induced Cytopathic Effect by Live-Cell Imaging
(2021-06-22)
Conventional plaque assays rely on the use of overlays to restrict viral infection allowing
the formation of distinct foci that grow in time as the replication cycle continues leading to countable
plaques that are ...
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
(2018-06)
Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ...
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
(2017)
Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ...