Listar Microbiología por título
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Production and partial characterization of monoclonal antibodies to Bothrops asper (terciopelo) myotoxin
(1988)Seven murine monoclonal antibodies against Bothrops aspen myotoxin were produced and partially characterized. They revealed the presence of at least four cross-reacting basic components in crude venom, with a common subunit ... -
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing
(BMC Genomics, 12:259, 2011, 2011)Background: A long term research goal of venomics, of applied importance for improving current antivenom therapy, but also for drug discovery, is to understand the pharmacological potential of venoms. Individually ... -
Programa de la evaluación externa de la calidad en coagulación sanguínea en Costa Rica utilizando plasma fresco congelado y de hematología básica con sangre estabilizada (PEEC- CIHATA-2020)
(2020-12-16)Informe sobre la evolución del Programa de Evaluación Externa del CIHATA. Repaso de conceptos y datos incluidos en el reporte. -
Promoting co-existence between humans and venomous snakes through increasing the herpetological knowledge base
(2021)Snakebite incidence at least partly depends on the biology of the snakes involved. However, studies of snake biology have been largely neglected in favour of anthropic factors, with the exception of taxonomy, which has been ... -
Pros and cons of different therapeutic antibody formats for recombinant antivenom development
(2018-05)Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being ... -
Proteoform-resolved quantitative venomics: looking through a crystal ball
(2017-04)In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the ... -
Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential
(2020)C. difficile induces antibiotic-associated diarrhea due to the action of two secreted toxins, TcdA and TcdB. A considerable range of virulence among C. difficile strains has been widely reported. During a hospital outbreak, ... -
Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase
(2013-03-27)Bothrops pirajai snake venom was analyzed by a proteomic strategy. Proteins were separated by RP-HPLC, followed by SDS-PAGE, in-gel tryptic digestion, identification by MALDI-TOF/TOF mass spectrometry, and assignment to ... -
Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?
(2023)Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned ... -
Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis)
(2017-01)Bothriechis is a genus of eleven currently recognized slender and arboreal venomous snakes, commonly called palm-pitvipers that range from southern Mexico to northern South America. Despite dietary studies suggesting that ... -
Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica
(2011-12)Venoms of the redtail coral snake Micrurus mipartitus from Colombia and Costa Rica were analyzed by “venomics”, a proteomic strategy to determine their composition. Proteins were separated by RP-HPLC, followed by SDS-PAGE, ... -
Proteomic and functional analysis of the venom of Porthidium lansbergii lansbergii (Lansberg’s hognose viper) from the Atlantic Department of Colombia
(2015)The venom of the Lansberg's hognose pitviper, Porthidium lansbergii lansbergii, a species found in the northern region of Colombia, is poorly known. Aiming to increase knowledge on Porthidium species venoms, its proteomic ... -
Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom
(Journal of Proteomics Volume 96, 16 January 2014, Pages 159–172, 2014-01)Bothrops ayerbei, a pitviper inhabiting the Patía River's basin (Valle Alto del Río Patía) in the Southwestern Department of Cauca, Colombia, was considered as a variant form of Bothrops asper prior to being proposed as a ... -
Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom
(2022)Coralsnakes belong to the family Elapidae and possess venoms which are lethal to humans and can be grouped based on the predominance of either three finger toxins (3FTxs) or phospholipases A2 (PLA2s). A proteomic and ... -
Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: The long-tailed rattlesnakes
(2022)The most enigmatic group of rattlesnakes is the long-tailed rattlesnake group, consisting of three species: Crotalus ericsmithi, Crotalus lannomi and Crotalus stejnegeri. These species have been the least studied rattlesnakes ... -
Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia
(Toxicon 90, 2014)Detailed snake venom proteomes for nearly a hundred species in different pitviper genera have accumulated using ‘venomics’ methodologies. However, venom composition for some lineages remains poorly known. Bothrocophias ... -
Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus
(2018-06)The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom ... -
Proteomic profile of the venom of three dark-colored Tityus (Scorpiones: Buthidae) from the tropical rainforests of Costa Rica
(2023)Objective: We aimed to elucidate the potential differences in the venom peptide sequences of three Tityus species from Costa Rican rainforests: T. jaimei, T. championi and T. dedoslargos, compared to T. cf. asthenes ... -
Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica
(2019)The genus Porthidium includes nine pitviper species inhabiting Mexico, Central America, and northern South America. Porthidium porrasi is a species endemic to the Southwest of Costa Rica, for which no information on ...