• Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities 

      Quesada Gómez, Carlos; López Ureña, Diana; Chumbler, Nicole; Kroh, Heather K.; Castro Peña, Carolina; Rodríguez Sánchez, César; Orozco Aguilar, Josué; González Camacho, Sara María; Rucavado Romero, Alexandra; Guzmán Verri, Caterina; Lawley, Trevor D.; Lacy, D. Borden; Chaves Olarte, Esteban (2016-03)
      Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ...
    • Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence 

      Quesada Gómez, Carlos; López Ureña, Diana; Chaves Olarte, Esteban; Acuña Amador, Luis Alberto; Villalobos Zúñiga, Manuel Antonio; Du, Tim; Freire, Rosemayre; Guzmán Verri, Caterina; Gamboa Coronado, María del Mar; Lawley, Trevor D.; Moreno Robles, Edgardo; Mulvey, Michael R.; de Castro Brito, Gerly Anne; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2015-04)
      The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...