Listar Microbiología por autor "8292b5b6-ec17-44bc-b00f-7540a228eb39"
Mostrando ítems 1-16 de 16
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A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia
Otero Patiño, Rafael; Gutiérrez, José María; Núñez Rangel, Vitelbina; Robles, Abel; Estrada Umaña, Ricardo; Segura, Eduardo; Toro, María Fabiola; García, M. E.; Díaz, Abel; Ramírez, Eugenio; Gómez, G.; Castañeda, J.; Moreno, M. E. (1996-12)A randomized double-blind clinical trial in 39 patients envenomed by Bothrops atrox in Antioquia and Chocó, Colombia, was performed to compare the efficacy and safety of 2 equine-derived antivenoms prepared at Instituto ... -
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom
Angulo Ugalde, Yamileth; Estrada Umaña, Ricardo; Gutiérrez, José María (1997-01)Six horses were immunized with the venoms of Bothrops asper, Crotalus durissus durissus and Lachesis muta stenophrys for the production of polyvalent (Crotalinae) antivenom. During the immunization, clinical and laboratory ... -
Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom
Olmedo, Hidekel; Herrera Vega, María; Rojas Sánchez, Leonardo; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Leiguez, Elbio; Teixeira, Catarina de Fátima; Estrada Umaña, Ricardo; Gutiérrez, José María; León Montero, Guillermo; Montero Villalobos, Mavis Lili (2014)The adjuvanticity of aluminum hydroxide and calcium phosphate on the antibody response in mice towards the venom of the snake Bothrops asper was studied. It was found that, in vitro, most of the venom proteins are similarly ... -
Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms
Dos Santos, María Cristina; Arroyo Portilla, Cynthia; Solano Rojas, Sergio; Herrera Vega, María; Villalta Arrieta, Mauren; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Gutiérrez, José María; León Montero, Guillermo (2011-02)Antivenoms are preparations of immunoglobulins purified from the plasma of animals immunized with snake venoms. Depending on the number of venoms used during the immunization, antivenoms can be monospecific (if venom from ... -
Desarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Rica
Estrada Umaña, Ricardo; Gutiérrez, José María; Alvarado, Jorge; Robles, Abel; Ávila Agüero, Claudio; González, Nuria (1989)The development of antibody response against phospholipase A activity of Bothrops asper venom was studied in a group of adult and healthy horses used in the production ofthe polyvalent antivenom at the Instituto Clodomiro ... -
Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms
Sánchez Brenes, Andrés; Coto Porras, Jorge; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Solano Trejos, María Gabriela; Herrera Vega, María; Villalta Arrieta, Mauren; Estrada Umaña, Ricardo; Gutiérrez, José María (2015-12-15)Two antivenoms prepared by using Echis ocellatus, Bitis arietans and Naja nigricollis venoms from different locations in sub-Saharan Africa were compared for their neutralizing ability. Both antivenoms were similarly ... -
Immune Response Towards Snake Venoms
León Montero, Guillermo; Sánchez Céspedes, Laura Vanessa; Hernández, Andrés; Villalta Arrieta, Mauren; Herrera Vega, María; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Gutiérrez, José María (2011)The immune response involves a complex repertoire of innate and adaptive responses to foreign agents in the organism. The present review focuses on the immune response to snake venoms, including those occurring in snakebite ... -
Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches
Gutiérrez, José María; Sanz, Libia; Flores Díaz, Marietta; Figueroa, Lucía; Madrigal Villalobos, Marvin; Herrera Vega, María; Villalta Arrieta, Mauren; León Montero, Guillermo; Estrada Umaña, Ricardo; Borges, Adolfo; Alape Girón, Alberto; Calvete Chornet, Juan José (2010-10-21)Intraspecific snake venom variations have implications in the preparation of venom pools for the generation of antivenoms. The impact of such variation in the cross-reactivity of antivenoms against Bothrops asper venom was ... -
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production
León Montero, Guillermo; Estrada Umaña, Ricardo; Chaves Mora, Fernando; Rojas Céspedes, Gustavo; Ovadia, Michael; Gutiérrez, José María (1998-03-26)The ability of the chelating agent CaNa2EDTA to inhibit local tissue damage induced by Bothrops asper venom was studied in mice and in horses used for polyvalent (Crotalinae) antivenom production. CaNa2EDTA was devoid of ... -
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows
Estrada Umaña, Ricardo; Herrera Vega, María; Segura Ruiz, Álvaro; Araya, Javier; Boschini Figueroa, Carlos; Gutiérrez, José María; León Montero, Guillermo (2010-11)Administration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting ... -
Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom
Arroyo Portilla, Cynthia; Solano Rojas, Sergio; Herrera Vega, María; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; León Montero, Guillermo (2015-09-01)The anti-bothropic activity of an antivenom prepared from the plasma of horses immunized with Bothrops asper venom (anti-B antivenom) was compared with a similar formulation produced from the plasma of horses immunized ... -
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: Comparison with two commercial antivenoms
Otero Patiño, Rafael; Núñez Rangel, Vitelbina; Gutiérrez, José María; Robles, Abel; Estrada Umaña, Ricardo; Osorio, Raúl Guillermo; Del Valle, G.; Valderrama, R.; Giraldo, Cesar Augusto (1997-04)Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atr-ox from Antioquia and Choco (Colombia). ... -
Preclinical evaluation of caprylic-acid fractionated IgG antivenom for the treatment of taipan (Oxyuranus scutellatus) envneoming in Papua New Guinea
Vargas Arroyo, Mariángela; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Estrada Umaña, Ricardo; Cerdas Solís, Maykel; Paiva, Owen K.; Matainaho, Teatulohi; Jensen, Simon D.; Winkel, Kenneth D.; León Montero, Guillermo; Gutiérrez, José María; Williams, David J. (PLoS Neglected Tropical Diseases 5 (5) e1144, 2011-05-17)Background: Snake bite is a common medical emergency in Papua New Guinea (PNG). The taipan, Oxyuranus scutellatus, inflicts a large number of bites that, in the absence of antivenom therapy, result in high mortality. ... -
Role of the animal model on the pharmacokinetics of equine-derived antivenoms
Rojas Araya, Alicia; Vargas Arroyo, Mariángela; Ramírez Arguedas, Nils Antonio; Estrada Umaña, Ricardo; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Gómez Argüello, Aarón; Gutiérrez, José María; León Montero, Guillermo (2013-08)Antivenom pharmacokinetics has been studied in heterologous models in which the animal species used as immunoglobulin source is different from that used as recipient. In these models, after intravenous administration of ... -
Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses
Villalta Arrieta, Mauren; Pla Ferrer, Davinia; Yang, Su Lin; Sanz, Libia; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Chen, Pei Yu; Herrera Vega, María; Estrada Umaña, Ricardo; Cheng, Ya Fen; Lee, Cheng Dow; Cerdas Solís, Maykel; Chiang, Jen Ron; Angulo Ugalde, Yamileth; León Montero, Guillermo; Calvete Chornet, Juan José; Gutiérrez, José María (2012-10-22)The proteomes of the venoms of the snakes Viridovipera stejnegeri and Protobothrops mucrosquamatus from Taiwan were characterized by N-terminal sequencing, MALDI-TOF mass fingerprinting, and collision-induced dissociation ... -
El suero antiofídico polivalente producido en Costa Rica: Estabilidad y capacidad neutralizante
Gutiérrez, José María; Lomonte, Bruno; Rojas Céspedes, Gustavo; Gené, José Antonio; Chaves Mora, Fernando; Estrada Umaña, Ricardo; Alvarado, Jorge; Rojas Umaña, Ermila; Robles, Abel (1988)En este trabajo se revisan y discuten una serie de aspectos relativos a la producción, estabilidad y capacidad neutralizante del suero antiofídico polivalente producido por el Instituto Clodomiro Picado. Este suero ...