Listar Biología por autor "Clardy, Jon"

Mostrando ítems 1-8 de 8

    • A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity 

      Ymele Leki, Patrick; Cao, Shugeng; Sharp, Jared ; Lambert, Kathleen G.; McAdam, Alexander J.; Husson, Robert N.; Tamayo Castillo, Giselle ; Clardy, Jon; Watnick, Paula I. (2012)
      Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and ...

    • Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts 

      Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi; MacArthur, Ryan; Dranchak, Patricia; Chlipala, George E.; Okoneski, Matthew T.; Guha, Rajarshi; Eastman, Richard T.; Yuan, Jing; Schultz, Pamela J.; Su, Xin-zhuan; Tamayo Castillo, Giselle; Matainaho, Teatulohi; Clardy, Jon; Sherman, David H.; Inglese, James (2015)
      Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...

    • Antifungal compounds 

      Van Arnam, Ethan B.; Sit, Clarissa Sau-Wei; Ruzzini, Antonio C.; Clardy, Jon; Currie, Cameron Robert; Pinto Tomás, Adrián A. (2013-06-03)
      Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claims.

    • Burkholderia from fungus gardens of fungus-growing ants produce antifungals that inhibit the specialized parasite Escovopsis. 

      Francoeur, Charlotte B.; May, Daniel S.; Thairu, Margaret W.; Hoang, Don Q.; Panthofer, Olivia; Bugni, Tim S.; Pupo, Monica Tallarico; Clardy, Jon; Pinto Tomás, Adrián A.; Currie, Cameron Robert (2021-06)
      Within animal-associated microbiomes, the functional roles of specific microbial taxa are often uncharacterized. Here, we use the fungus-growing ant system, a model for microbial symbiosis, to determine the potential ...

    • Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A 

      Lee, Seulah; Tamayo Castillo, Giselle; Pang, Changhyun; Clardy, Jon; Cao, Shugeng; Kim, Ki Hyun (2016-05-15)
      Three new diketopiperazines (1–3), cyclo(l-Pro-d-trans-Hyp) (1), cyclo(l-Pro-d-Glu) (2), and cyclo(d-Pro-d-Glu) (3) and five known diketopiperazines (4–8) were isolated from the endolichenic fungus Colpoma sp. CR1465A ...

    • Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp. 

      Cao, Shugeng; McMillin, Douglas W.; Tamayo Castillo, Giselle; Delmore, Jake; Mitsiades, Constantine S.; Clardy, Jon (2012)
      CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context of ...

    • Pollen Streptomyces Produce Antibiotic That Inhibits the Honey Bee Pathogen Paenibacillus larvae 

      Grubbs, Kirk J.; May, Daniel S.; Sardina, Joseph A.; Dermenjian, Renee K.; Wyche, Thomas P.; Pinto Tomás, Adrián A.; Clardy, Jon; Currie, Cameron Robert (2021)
      Humans use natural products to treat disease; similarly, some insects use natural products produced by Actinobacteria to combat infectious pathogens. Honey bees, Apis mellifera, are ecologically and economically important ...

    • Selvamicin, an atypical antifungal polyene from two alternative genomic contexts 

      Van Arnam, Ethan B.; Ruzzini, Antonio C.; Sit, Clarissa Sau-Wei; Horn, Heidi A.; Pinto Tomás, Adrián A.; Currie, Cameron Robert; Clardy, Jon (2016-11-15)
      The bacteria harbored by fungus-growing ants produce a variety of small molecules that help maintain a complex multilateral symbiosis. In a survey of antifungal compounds from these bacteria, we discovered selvamicin, an ...