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Modulation of the Susceptibility of Human Erythrocytes to Snake Venom Myotoxic Phospholipases A2: Role of Negatively Charged Phospholipids as Potential Membrane Binding Sites
(2001-07-01)
Cerrophidion (Bothrops) godmani myotoxins I (CGMT-I) and II (CGMT-II), Asp-49 and Lys-49 phospholipases A(2) (PLA2s), which drastically differ in enzymatic activity, were devoid of direct hemolytic effects on erythrocytes ...
The Novel Phages phiCD5763 and phiCD2955 Represent Two Groups of Big Plasmidial Siphoviridae Phages of Clostridium difficile
(2018-01)
Until recently, Clostridium difficile phages were limited to Myoviruses and Siphoviruses of medium genome length (32–57 kb). Here we report the finding of phiCD5763, a Siphovirus with a large extrachromosomal circular ...
Resistencia a insecticidas en cepas de Aedes aegypti (Diptera: Culicidae) de tres distritos de la Región Pacífico Central de Costa Rica
Insecticide resistance in Aedes aegypti (Diptera: Culicidae) strains from three districts of the Central Pacific Region of Costa Rica
(2018-12-30)
Introducción: Aedes aegypti es vector de virus dengue, chikungunya y Zika en Costa Rica. Su alta incidencia y carencia de vacunas hacen del control vectorial, incluyendo el químico, la única alternativa para disminuir su ...
First Report of the Isolation and Molecular Characterization of Rickettsia amblyommii and Rickettsia felis in Central America
(2011-10-05)
During 2010, 15 adult ticks, identified as Amblyomma cajennense, were collected from horses in Cahuita and Turrialba districts, whereas 7 fleas, identified as
Ctenocephalides felis, were collected from a dog in San Jose ...
Effect of a recombinant Lys49 PLA2 myotoxin and Lys49 PLA2-derived synthetic peptides from Agkistrodon species on membrane permeability to water.
(2004)
The aim of this work was to study the effect of recombinant ACL myotoxin, a Lys49PLA2 from Agkistrodon contortrix
laticinctus snake venom and Lys49PLA2-derived synthetic peptides corresponding to the region 115–129 of ...
Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?
(Peer Journal 2:e569; DOI 10.7717/peerj.569, 2014-09-16)
Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms,
relevant to development of myonecrosis. Given their difference in catalytic
activity, mechanistic studies on each type require highly ...
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
(2018-06)
Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ...
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment
(2005-06)
Envenomations after bites inflicted by snakes of the genus Bothrops constitute a public health hazard in Perú, and the intravenous administration of equine-derived antivenoms represents the only scientifically validated ...
Actualización de la Terapia Antitrombótica
(2018)
La hemostasia es un proceso dinámico que tiene como componentes principales a las plaquetas, la cascada de coagulación y el sistema fibrinolítico; todos elementos fundamentales para el correcto funcionamiento de la ...