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Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
(2000-11)The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ... -
Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin
(2005-06-15)Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ... -
Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture
(1997-06)This study screened 25 sera, 19 synthetic products and five antivenoms obtained after immunization for their ability to neutralize the hemorrhagic activity of venom from the snake Bothrops asper. Among the sera screened, ... -
Inhibition of the myotoxic activity of Bothrops aspermyotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129
(1999)The region comprising amino acid residues 115±129 of myotoxin II, a Lys49 phospholipase A2 from the venom of Bothrops asper, was previously shown to constitute a heparin binding site, and to be associated with its toxic ... -
Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture
(1997-12)The majority of snake bites in Central America are caused by Bothrops asper, whose venom induce complex local effects such as myonecrosis, edema and especially hemorrhage. These effects are only partially neutralized by ... -
Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.
(2012)CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context of ... -
Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2
(2003)Myotoxic phospholipases A2 account for most of the muscle necrosis that results from envenenomation by crotaline snakes. In this study, we investigated the protective effect of fucoidan, a natural sulfated polysaccharide ... -
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
(2005)Phospholipases A2 (PLA2) are important constituents of snake venoms, being responsible for several of their toxic actions. Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity ... -
Iniciativa de creación de una Red de Preservación Digital en Latinoamérica
(I SINPRED - Seminário Internacional de Preservação Digital e III Encontro Nacional da Rede Cariniana, mayo 2014, 2014-05)La evolución tecnológica ha obligado a las bibliotecas universitarias crear herramientas de captura y visualización de la producción académica universitaria. Ante la gran cantidad de información presente en la web, las ... -
Iniciativas de acceso abierto en las publicaciones académicas de la Facultad de Ciencias Sociales de la Universidad de Costa Rica
(INIE, 2012)Las universidades, institutos o centros de investigación, conforman las entidades con mayor producción de publicaciones científicas con avances y resultados del nuevo conocimiento originado por los científicos en sus ... -
Inicio de la temporada de lluvias en América Central
(2021)Los comienzos tempranos (tardíos) de la temporada de lluvias en América Central, tienden a estar asociados con periodos en mayo-junio más lluviosos (más secos), siendo este el primer pico de la temporada de lluvias. El ... -
El inicio de la temporada navideña en Costa Rica
(2017-12-17)El documento trata sobre las obras navideñas en los teatros nacionales de Costa Rica. -
Los inicios frustrados de la mecanización de la agricultura costarricense entre 1900 y 1950. La difusión del arado y del tractor. Actores, tecnología agrícola, discursos y representaciones desde una perspectiva transnacional
(2020)En este capítulo se estudian los inicios frustrados de la mecanización de la agricultura costarricense entre 1900 y 1950, a partir de la difusión del arado y del tractor. Especial atención recibe el análisis de los actores, ... -
INIL-VIII Jornadas de Investigación: Pragmatics and Emotions
(2023-12-10)VIII Jornadas de Investigación del INIL Plenaria "Pragmatics and Emotions" a cargo del Prof. Louis de Saussure (Université de Neuchâtel). Instituto de Investigaciones Lingüísticas (INIL) Universidad de Costa ... -
Initial metabolic state and exercise-induced endotoxaemia are unrelated to gastrointestinal symptoms during exercise
(2009-06)The aim of the study was to investigate the association between the initial metabolic state and exercise-induced endotoxaemia on the appearance of gastrointestinal symptoms (GIS) during exer-cise. Eleven males ...