Show simple item record

dc.creatorCastillo Henríquez, Luis
dc.creatorMadrigal Redondo, German
dc.creatorVargas Zúñiga, Rolando
dc.creatorCarazo Berrocal, Gustavo
dc.date.accessioned2020-04-28T20:19:43Z
dc.date.available2020-04-28T20:19:43Z
dc.date.issued2018
dc.identifier.citationhttps://www.journalajst.com/identification-rupatadine-fumarate-polymorphic-crystalline-forms-pharmaceutical-raw-materialses_ES
dc.identifier.issn0976-3376
dc.identifier.urihttp://hdl.handle.net/10669/80938
dc.description.abstractPolymorphism analysis of pharmaceutical raw materials is considered one of the most relevant evaluations that should be done. As we know, different crystal forms from the same molecule have differences in terms of their physicochemical properties. According to the crystal form used, researchers can obtain benefits for the development of a new product or it can also imply a disadvantage for the formulation of the product. The present study focuses on the identification of crystalline forms in Rupatadine Fumarate raw material samples. The active pharmaceutical ingredient is an antihistaminic, classified as a second-generation selective H1 receptor, which shows advantages in terms of solubility in contrast with the free base and the trichloride form. Analytical techniques employed were: X ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and infrared spectroscopy. The results were analyzed all together and compared with the information found in literature. Based on the results obtained, it was demonstrated that the analyzed drug samples don´t present any other polymorphic form besides A form, which is the only one reported in literature.es_ES
dc.language.isoen_USes_ES
dc.sourceAsian Journal of Science and Technology, vol.09(02), pp.7482-7487es_ES
dc.subjectActive pharmaceutical Ingredientes_ES
dc.subjectAntihistaminices_ES
dc.subjectDifferential scanninges_ES
dc.subjectCalorimetryes_ES
dc.subjectInfrared spectroscopyes_ES
dc.subjectPharmaceutical polymorphismes_ES
dc.subjectRupatadine fumaratees_ES
dc.subjectThermogravimetric analysises_ES
dc.subjectX ray diffractiones_ES
dc.titleIdentification of rupatadine fumarate polymorphic crystalline forms in pharmaceutical raw materialses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record