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dc.creatorRucavado Romero, Alexandra
dc.creatorLomonte, Bruno
dc.date.accessioned2017-09-26T20:25:55Z
dc.date.available2017-09-26T20:25:55Z
dc.date.issued1996
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/004101019500162X?via%3Dihubes_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/73298
dc.description.abstractThe ability of pre-existing antibodies to neutralize locally-acting toxins of Bothrops asper snake venom was investigated. Hemorrhage, myonecrosis, and edema were markedly reduced in actively immunized mice, although none of these effects was completely abolished. In mice passively immunized with equine antivenom, hemorrhage was prevented completely, while myonecrosis and edema were partially reduced. Pre-existing antibodies did not modify the early stage ( < 3 hr) of venom-induced edema, but significantly accelerated the normalization of this effect within 24 hr. Passive administration of antivenom either 5 or 120 min before venom injection gave similar results, suggesting that the presence of antibodies in the intravascular compartment may fully neutralize locally acting toxins, in this experimental animal model. Overall, the homologous or heterologous origin of antibodies was not a significant factor influencing their in uit,o neutralizing efficiency against local venom effects. Antibody titrations by enzyme-immunoassay using purified toxins and whole venom indicated that serum from actively-immunized mice had a higher proportion of anti-myotoxin antibodies than equine antivenom.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[VI-741-95-264]/UCR/Costa Ricaes_ES
dc.description.sponsorshipInternational Foundation for Science/[F/1388-3F]/IFS/Sueciaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon, Vol. 34, Núm. 5, 1996es_ES
dc.subjectSnake venomes_ES
dc.subjectBothropses_ES
dc.subjectAntibodieses_ES
dc.titleNeutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in micees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(95)00162-X
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid8783451


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