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dc.creatorArroyo Portilla, Cynthia
dc.creatorSolano Rojas, Sergio
dc.creatorHerrera Vega, María
dc.creatorSegura Ruiz, Álvaro
dc.creatorEstrada Umaña, Ricardo
dc.creatorVargas Arroyo, Mariángela
dc.creatorVillalta Arrieta, Mauren
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2017-07-07T15:05:06Z
dc.date.available2017-07-07T15:05:06Z
dc.date.issued2015-09-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010115001634es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/30336
dc.description.abstractThe anti-bothropic activity of an antivenom prepared from the plasma of horses immunized with Bothrops asper venom (anti-B antivenom) was compared with a similar formulation produced from the plasma of horses immunized with a mixture of B. asper and Lachesis stenophrys venoms (anti-BL antivenom). Likewise, a comparison between the anti-lachesic activity of the anti-BL antivenom and a similar formulation prepared from horses immunized only with L. stenophrys venom (anti-L antivenom) was performed. The anti-BL antivenom had lower concentration of anti-bothropic antibodies than the anti-B antivenom. This difference was associated to a lower response towards all components of B. asper venom, but particularly towards some D49-phospholipases A2 (PLA2s) and PIII-metalloproteinases. Consequently, the anti-BL antivenom was less effective neutralizing lethal, coagulant, defibrinogenating, PLA2, and myotoxic activities of B. asper venom. On the other hand, anti-BL and anti-L antivenoms showed similar concentration of anti-lachesic antibodies, and similar capacity to recognize the HPLC fractions of L. stenophrys venom and to neutralize lethal, coagulant, proteolytic, hemorrhagic, PLA2 and myotoxic activities induced by this venom. It is concluded that, when used as co-immunogens, the venom of L. stenophrys reduces the antibody response towards B. asper venom, whereas the latter does not affect the anti-lachesic response.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B2-601]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 103. 2015es_ES
dc.subjectSnake venomes_ES
dc.subjectBothrops asperes_ES
dc.subjectLachesis stenophryses_ES
dc.subjectImmunizationes_ES
dc.subjectImmunomodulationes_ES
dc.subjectSnake antivenomes_ES
dc.titleLachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2015.06.016
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-B2-601
dc.identifier.pmid26100664


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