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dc.creatorQuesada, Lil
dc.creatorSevcik, Carlos
dc.creatorLomonte, Bruno
dc.creatorRojas Umaña, Ermila
dc.creatorGutiérrez, José María
dc.date.accessioned2016-12-12T21:23:12Z
dc.date.available2016-12-12T21:23:12Z
dc.date.issued2006-09-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010106001929es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29392
dc.description.abstractPharmacokinetics of antivenoms has been mainly studied in normal animals, whereas very little is known on pharmacokinetics in envenomed animals. The aim of this study was to compare pharmacokinetic parameters of whole IgG equine antivenom in normal rabbits and in rabbits suffering a moderate envenoming by intramuscular injection of the venom of the viperid snake Bothriechis lateralis, which induces drastic microvascular alterations. Anti-Micrurus nigrocinctus antivenom was used, instead of polyvalent (Crotalinae) antivenom, to avoid the formation of toxin–antibody complexes which may alter antivenom pharmacokinetics. It was thus possible to study the effect of vascular alterations, i.e., edema and hemorrhage, induced by the venom on IgG antivenom distribution and elimination. An ELISA was utilized to quantify equine IgG antivenom concentration in rabbit serum. In addition, the amount of IgG antivenom extravasated in injected muscles was also determined. Results indicate that there were no significant differences, between control and envenomed rabbits, in any of the pharmacokinetic parameters investigated, thus suggesting that a moderate envenoming by this viperid species does not alter the pharmacokinetics of IgG antivenom. A significantly higher amount of antivenom IgG was observed in muscle from envenomed rabbits than in muscle from control animals. However, this corresponds to a low percentage of the administered antivenom and, therefore, this increased local extravasation does not have a significant impact in the overall antivenom pharmacokinetics.es_ES
dc.description.sponsorship/[02-N-2003]/NeTropica/Estados Unidoses_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A4-503]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 48, Número 3. 2006es_ES
dc.subjectAntivenomes_ES
dc.subjectIgGes_ES
dc.subjectEnvenominges_ES
dc.subjectPharmacokineticses_ES
dc.subjectSnake venomes_ES
dc.titlePharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbitses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2006.05.010
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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