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Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action
dc.creator | Montecucco, Cesare | |
dc.creator | Gutiérrez, José María | |
dc.creator | Lomonte, Bruno | |
dc.date.accessioned | 2016-11-18T21:26:03Z | |
dc.date.available | 2016-11-18T21:26:03Z | |
dc.date.issued | 2008-06-20 | |
dc.identifier.citation | http://link.springer.com/article/10.1007%2Fs00018-008-8113-3 | |
dc.identifier.issn | 1420-9071 | |
dc.identifier.uri | https://hdl.handle.net/10669/29265 | |
dc.description.abstract | A large variety of snake toxins evolved from PLA2 digestive enzymes through a process of ‘accelerated evolution’. These toxins have different tissue targets, membrane receptors and mechanisms of alteration of the cell plasma membrane. Two of the most commonly induced effects by venom PLA2s are neurotoxicity and myotoxicity. Here, we will discuss how these snake toxins achieve a similar cellular lesion, which is evolutionarily highly conserved, despite the differences listed above. They cause an initial plasma membrane perturbation which promotes a large increase of the cytosolic Ca2+ concentration leading to cell degeneration, following modes that we discuss in detail for muscle cells and for the neuromuscular junction. The different systemic pathophysiological consequences caused by these toxins are not due to different mechanisms of cell toxicity, but to the intrinsic anatomical and physiological properties of the targeted tissues and cells. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Cellular and Molecular Life Sciences; Volumen 65, Número 18. 2008 | es_ES |
dc.subject | PLA2 | es_ES |
dc.subject | Neurotoxins | es_ES |
dc.subject | Myotoxins | es_ES |
dc.subject | Ca2+ | es_ES |
dc.subject | Snake venom | es_ES |
dc.title | Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1007/s00018-008-8113-3 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
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Microbiología [1171]