Listar Microbiología por autor "Saravia Otten, Patricia"
Mostrando ítems 1-7 de 7
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Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture
Saravia Otten, Patricia; Robledo, Bárbara; Escalante Muñoz, Teresa; Bonilla, Llira; Rucavado Romero, Alexandra; Lomonte, Bruno; Hernández, Rosario; Flock, Jan-Ingmar; Gutiérrez, José María; Gastaldello, Stefano (2013-02)Introduction: Viperid snakebite envenomings are characterized by muscle necrosis and a deficient regenerative response. Methods: Homogenates from gastrocnemius muscles of mice injected with the venom of the snake Bothrops ... -
Increased Infectivity of Staphylococcus aureus in an Experimental Model of Snake Venom–Induced Tissue Damage
Saravia Otten, Patricia; Gutiérrez, José María; Arvidson, Staffan; Thelestam, Mónica; Flock, Jan-Ingmar (2007-09-01)Soft-tissue infection is commonly found in patients bitten by Latin American Bothrops snakes. Staphylococcus aureus, which is not present in the mouth of the snake, is frequently isolated from these infections. The effects ... -
Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu
Pérez, Aida Verónica; Saravia Otten, Patricia; Rucavado Romero, Alexandra; Sant’Ana, Carolina D.; Soares, Andreimar Martins; Gutiérrez, José María (2007-06-01)The local and systemic pathophysiological alterations induced by BjussuSP-I, a thrombin-like serine proteinase from the venom of the snake Bothrops jararacussu, were assessed in mice. BjussuSP-I induced a mild edema but ... -
Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases
Saravia Otten, Patricia; Frisan, Teresa; Thelestam, Mónica; Gutiérrez, José María (2004-12-01)ProMMP-2 activation by Bothrops asper venom was investigated in mouse gastrocnemius muscle, mammalian cell culture and a cell-free system. Zymography revealed an increment of latent and activated forms of MMP-2 in muscle ... -
Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves
Hernández, Rosario; Cabalceta, Carmen; Saravia Otten, Patricia; Chaves, Alessandra; Gutiérrez, José María; Rucavado Romero, Alexandra (PLoS ONE 6(5): e19834, 2011-05-24)Background: Viperid snakebite envenoming is characterized by prominent local tissue damage, including muscle necrosis. A frequent outcome of such local pathology is deficient skeletal muscle regeneration, which causes ... -
The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms
Saravia Otten, Patricia; Rojas Umaña, Ermila; Escalante Muñoz, Teresa; Arce, Viviana; Chaves Olarte, Esteban; Velásquez, Rubén; Lomonte, Bruno; Rojas Céspedes, Gustavo; Gutiérrez, José María (2001-02)Bothrops asper is responsible for approximately half of the snakebite envenomations in Central America. Despite its medical relevance, only the venom of Costa Rican populations of this species has been studied to some ... -
Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms
Rojas Umaña, Ermila; Saravia Otten, Patricia; Angulo Ugalde, Yamileth; Arce, Viviana; Lomonte, Bruno; Chávez, Juan José; Velásquez, Rubén; Thelestam, Mónica; Gutiérrez, José María (2001-07)A comparative study was performed on the venoms of the crotaline snake Atropoides nummifer from Guatemala and Honduras. SDS-polyacrylamide gel electrophoresis, under reducing conditions, revealed a highly similar pattern ...