Listar Microbiología por autor "Kop Montero, Mariana"
Mostrando ítems 1-4 de 4
-
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
Molina Mora, José Arturo; Kop Montero, Mariana; Quirós Fernández, Isaac; Quirós Barrantes, Steve; Crespo Mariño, Juan Luis; Mora Rodríguez, Rodrigo Antonio (2018-06)Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
Molina Mora, José Arturo; Quirós Barrantes, Steve; Kop Montero, Mariana; Mora Rodríguez, Rodrigo Antonio; Crespo Mariño, Juan Luis (2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
Quirós Fernández, Isaac; Molina Mora, José Arturo; Kop Montero, Mariana; Salas Hidalgo, Elvira; Mora Rodríguez, Rodrigo Antonio (2018)Cancer is a group of heterogeneous and complex diseases, with limited therapeutic options due to the recurrent emergence of drug resistance. Sphingolipids are bioactive molecules that participate in signaling of cell ... -
Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle
Molina Mora, José Arturo; Mesén Porras, Susana; Quirós Fernández, Isaac; Kop Montero, Mariana; Rojas Céspedes, Andrea; Quirós Barrantes, Steve; Siles Canales, Francisco; Mora Rodríguez, Rodrigo Antonio (2022-12)Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and drug multiresistance emergence. The sphingolipid (SL) metabolic pathway integrates different responses of cellular ...