Listar Microbiología por autor "f2bb6a48-1691-401b-b78e-5e5b3213ceaa"
Mostrando ítems 1-8 de 8
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A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements
Ramírez Vargas, Gabriel; Quesada Gómez, Carlos; Acuña Amador, Luis Alberto; López Ureña, Diana; Murillo Corrales, Tatiana; Gamboa Coronado, María del Mar; Chaves Olarte, Esteban; Thomson, Nicholas R.; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2017-01)The antimicrobial resistance (AMR) rates and levels recorded for Clostridium difficile are on the rise. This study reports the nature, levels, diversity, and genomic context of the antimicrobial resistance of human C. ... -
A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption
Leite Costa, Cecília; López Ureña, Diana; de Oliveira Assis, Thiago; Ribeiro, Ronaldo de Albuquerque; Silveira Silva, Rodrigo Otavio; Rupnik, Maja; Wilcox, Mark H.; Fiorini de Carvalho, Alex; Oliveira do Carmo, Anderson; Abalen Martins Dias, Adriana; Barreto Mano de Carvalho, Cibele; Chaves Olarte, Esteban; Rodríguez Sánchez, César; Quesada Gómez, Carlos; de Castro Brito, Gerly Anne (2016-08)The epidemiology of Clostridium difficile infections is highly dynamic as new strains continue to emerge worldwide. Here we present a detailed analysis of a new C. difficile strain (ICC-45) recovered from a cancer patient ... -
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
Quesada Gómez, Carlos; López Ureña, Diana; Chumbler, Nicole; Kroh, Heather K.; Castro Peña, Carolina; Rodríguez Sánchez, César; Orozco Aguilar, Josué; González Camacho, Sara María; Rucavado Romero, Alexandra; Guzmán Verri, Caterina; Lawley, Trevor D.; Lacy, D. Borden; Chaves Olarte, Esteban (2016-03)Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ... -
Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence
Quesada Gómez, Carlos; López Ureña, Diana; Chaves Olarte, Esteban; Acuña Amador, Luis Alberto; Villalobos Zúñiga, Manuel Antonio; Du, Tim; Freire, Rosemayre; Guzmán Verri, Caterina; Gamboa Coronado, María del Mar; Lawley, Trevor D.; Moreno Robles, Edgardo; Mulvey, Michael R.; de Castro Brito, Gerly Anne; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2015-04)The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ... -
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements
Ramírez Vargas, Gabriel; López Ureña, Diana; Badilla Lobo, Adriana; Orozco Aguilar, Josué; Murillo Corrales, Tatiana; Rojas, Priscilla; Riedel, Thomas; Overmann, Jörg; González, Gabriel; Chaves Olarte, Esteban; Quesada Gómez, Carlos; Rodríguez Sánchez, César (2018)The population structure of Clostridium difficile currently comprises eight major genomic clades. For the highly divergent C-I clade, only two toxigenic strains have been reported, which lack the tcdA and tcdC genes and ... -
Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks
López Ureña, Diana; Quesada Gómez, Carlos; Montoya Ramírez, Mónica; Gamboa Coronado, María del Mar; Somogyi Pérez, Teresa; Rodríguez Sánchez, César; Rodríguez Cavallini, Evelyn (2016-05)Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficileassociated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent ... -
Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential
Quesada Gómez, Carlos; Murillo Corrales, Tatiana; Arce, Grettel; Badilla Lobo, Adriana; Castro Peña, Carolina; Molina Mora, José Arturo; López Ureña, Diana; González Camacho, Sara María; Lomonte, Bruno; Chacón Díaz, Carlos; Rodríguez Sánchez, César; Chaves Olarte, Esteban (2020)C. difficile induces antibiotic-associated diarrhea due to the action of two secreted toxins, TcdA and TcdB. A considerable range of virulence among C. difficile strains has been widely reported. During a hospital outbreak, ... -
Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
López Ureña, Diana; Orozco Aguilar, Josué; Chaves Madrigal, Yendry Pamela; Ramírez Mata, Andrea; Villalobos Jimenez, Amanda; Ost, Stefan; Quesada Gómez, Carlos; Rodríguez Sánchez, César; Papatheodorou, Panagiotis; Chaves Olarte, Esteban (2019)Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence ...