Listar Microbiología por autor "57a23b6b-8111-4506-a781-c469e89c1d61"
Mostrando ítems 1-3 de 3
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Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
Quesada Gómez, Carlos; López Ureña, Diana; Chumbler, Nicole; Kroh, Heather K.; Castro Peña, Carolina; Rodríguez Sánchez, César; Orozco Aguilar, Josué; González Camacho, Sara María; Rucavado Romero, Alexandra; Guzmán Verri, Caterina; Lawley, Trevor D.; Lacy, D. Borden; Chaves Olarte, Esteban (2016-03)Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ... -
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements
Ramírez Vargas, Gabriel; López Ureña, Diana; Badilla Lobo, Adriana; Orozco Aguilar, Josué; Murillo Corrales, Tatiana; Rojas, Priscilla; Riedel, Thomas; Overmann, Jörg; González, Gabriel; Chaves Olarte, Esteban; Quesada Gómez, Carlos; Rodríguez Sánchez, César (2018)The population structure of Clostridium difficile currently comprises eight major genomic clades. For the highly divergent C-I clade, only two toxigenic strains have been reported, which lack the tcdA and tcdC genes and ... -
Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
López Ureña, Diana; Orozco Aguilar, Josué; Chaves Madrigal, Yendry Pamela; Ramírez Mata, Andrea; Villalobos Jimenez, Amanda; Ost, Stefan; Quesada Gómez, Carlos; Rodríguez Sánchez, César; Papatheodorou, Panagiotis; Chaves Olarte, Esteban (2019)Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence ...