Listar Microbiología por autor "09c0729a-2c5d-4018-b931-7175ae375509"

Mostrando ítems 1-16 de 16

    • Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities 

      Quesada Gómez, Carlos; López Ureña, Diana; Chumbler, Nicole; Kroh, Heather K.; Castro Peña, Carolina; Rodríguez Sánchez, César; Orozco Aguilar, Josué; González Camacho, Sara María; Rucavado Romero, Alexandra; Guzmán Verri, Caterina; Lawley, Trevor D.; Lacy, D. Borden; Chaves Olarte, Esteban (2016-03)
      Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ...

    • Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas 

      Campos Sánchez, Rebeca; Flores Cruz, Andrés; Molina Mora, José Arturo; Mora Rodríguez, Rodrigo Antonio; Rodríguez Sánchez, César; Gatica Arias, Andrés Mauricio; Guzmán Verri, Caterina (2021-11-09)
      Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ...

    • Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide 

      Barquero Calvo, Elías; Mora Cartín, Ricardo; Arce Gorvel, Vilma; de Diego, Juana L.; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Buret, Andre G.; Gorvel, Jean Pierre; Moreno Robles, Edgardo (2015-05-06)
      Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ...

    • Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains 

      Suárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Castillo Zeledón, Amanda; Jiménez Rojas, César; Martin Roop II, Roy; Comerci, Diego J.; Barquero Calvo, Elías; Chacón Díaz, Carlos; Caswell, Clayton C.; Baker, Kate S.; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Letesson, Jean J.; De Bolle, Xavier; Guzmán Verri, Caterina (2016-09-29)
      Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research ...

    • Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts 

      Chacón Díaz, Carlos; Altamirano Silva, Pamela; González Espinoza, Gabriela; Medina, María Concepción; Alfaro Alarcón, Alejandro; Bouza Mora, Laura; Jiménez Rojas, César; Wong Araya, Melissa; Barquero Calvo, Elías; Rojas Campos, Norman; Guzmán Verri, Caterina; Moreno Robles, Edgardo; Chaves Olarte, Esteban (2015-11-10)
      Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...

    • Brucella Genetic Variability in Wildlife Marine Mammals Populations Relates to Host Preference and Ocean Distribution 

      Suárez Esquivel, Marcela; Baker, Kate S.; Ruiz Villalobos, Nazareth; Hernández Mora, Gabriela; Barquero Calvo, Elías; Castillo Zeledón, Amanda; Jiménez Rojas, César; Chacón Díaz, Carlos; Cloeckaert, Axel; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Guzmán Verri, Caterina; González Barrientos, Rocío (2017)
      Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ...

    • Brucella neotomae Infection in Humans, Costa Rica 

      Suárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Jiménez Rojas, César; Barquero Calvo, Elías; Chacón Díaz, Carlos; Víquez Ruiz, Eunice; Rojas Campos, Norman; Baker, Kate S.; Oviedo Sánchez, Gerardo; Amuy, Ernesto; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Guzmán Verri, Caterina (2017-06)
      Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...

    • Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports 

      Villalobos Vindas, Juan M.; Amuy, Ernesto; Barquero Calvo, Elías; Rojas Campos, Norman; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Moreno Robles, Edgardo (2017-12-19)
      Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified two ...

    • Brucellosis in mammals of Costa Rica: An epidemiological survey 

      Hernández Mora, Gabriela; Bonilla Montoya, Roberto; Barrantes Granados, Osvaldo; Esquivel Suárez, Andrea; Montero Caballero, Danilo; González Barrientos, Rocío; Fallas Monge, Zeanne; Palacios Alfaro, José David; Baldi Salas, Mario; Campos Chacón, Elena; Chanto Chacón, Grettel; Barquero Calvo, Elías; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Romero Zúñiga, Juan José; Moreno Robles, Edgardo (2017-08-09)
      Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in the ...

    • Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence 

      Quesada Gómez, Carlos; López Ureña, Diana; Chaves Olarte, Esteban; Acuña Amador, Luis Alberto; Villalobos Zúñiga, Manuel Antonio; Du, Tim; Freire, Rosemayre; Guzmán Verri, Caterina; Gamboa Coronado, María del Mar; Lawley, Trevor D.; Moreno Robles, Edgardo; Mulvey, Michael R.; de Castro Brito, Gerly Anne; Rodríguez Cavallini, Evelyn; Rodríguez Sánchez, César (2015-04)
      The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...

    • Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease 

      Hernández Mora, Gabriela; Ruiz Villalobos, Nazareth; Bonilla Montoya, Roberto; Romero Zúñiga, Juan José; Jiménez Arias, Julio; González Barrientos, Rocío; Barquero Calvo, Elías; Chacón Díaz, Carlos; Rojas Campos, Norman; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Moreno Robles, Edgardo (2017-08)
      Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR were ...

    • Intracellular passage triggers a molecular response in that increases its infectiousness 

      Altamirano Silva, Pamela; Cordero Serrano, Marlen; Méndez Montoya, Joselyn; Chacón Díaz, Carlos; Guzmán Verri, Caterina; Moreno Robles, Edgardo; Chaves Olarte, Esteban (2021)
      Brucella abortus is a facultative extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h post-infection) ...

    • Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation 

      Altamirano Silva, Pamela; Meza Torres, Jazmín Andrea; Zúñiga Pereira, Ana Mariel; Zamora Jaen, Sigrid; Pietrosemoli, Natalia; Cantos González, Gabriela; Peltier, Johann; Pizarro Cerdá, Javier; Moreno Robles, Edgardo; Chacón Díaz, Carlos; Guzmán Verri, Caterina; Chaves Olarte, Esteban (2023-04)
      Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive intracellularly at the endoplasmic reticulum derived compartment. The two-component system BvrR/BvrS (BvrRS) is essential for ...

    • Senses the Intracellular Environment through the BvrR/BvrS Two-Component System, Which Allows To Adapt to Its Replicative Niche 

      Altamirano Silva, Pamela; Meza Torres, Jazmín Andrea; Castillo Zeledón, Amanda; Ruiz Villalobos, Nazareth; Zúñiga Pereira, Ana Mariel; Chacón Díaz, Carlos; Moreno Robles, Edgardo; Guzmán Verri, Caterina; Chaves Olarte, Esteban (2018-03-22)
      Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ...

    • Two Groups of Cocirculating, Epidemic Clostridiodes difficile Strains Microdiversify through Different Mechanisms 

      Murillo Corrales, Tatiana; Ramírez Vargas, Gabriel; Riedel, Thomas; Overmann, Jörg; Andersen, Joakim M; Guzmán Verri, Caterina; Chaves Olarte, Esteban; Rodríguez Sánchez, César (2018-03)
      Clostridiodes difficile strains from the NAPCR1/ST54 and NAP1/ST01 types have caused outbreaks despite of their notable differences in genome diversity. By comparing whole genome sequences of 32 NAPCR1/ST54 isolates and ...

    • Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals 

      Hernández Mora, Gabriela; Chacón Díaz, Carlos; Moreira Soto, Andrés; Barrantes Granados, Osvaldo; Suárez Esquivel, Marcela; Víquez Ruiz, Eunice; Barquero Calvo, Elías; Ruiz Villalobos, Nazareth; Hidalgo Montealegre, Daniela; González Barrientos, Rocío; Demeter, Elena A.; Estrella Morales, Josimar; Zúñiga Pereira, Ana Mariel; Quesada Gómez, Carlos; Chaves Olarte, Esteban; Lomonte, Bruno; Guzmán Verri, Caterina; Drexler, Jan Felix; Moreno Robles, Edgardo (2023)
      Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical and tropical areas of the American continent. Here, we report ...