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dc.creatorArias, Tomas D.
dc.creatorJorge, L. F.
dc.creatorLee, D
dc.creatorBarrantes Mesén, Ramiro
dc.creatorInaba, T.
dc.date.accessioned2016-02-03T20:07:09Z
dc.date.available2016-02-03T20:07:09Z
dc.date.issued1988-04-20
dc.identifier.citationhttp://onlinelibrary.wiley.com/doi/10.1038/clpt.1988.58/epdfes_ES
dc.identifier.issn1532-6535
dc.identifier.urihttp://hdl.handle.net/10669/15559
dc.descriptionArtículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1988es_ES
dc.description.abstractSparteine sulfate (50 mg) was administered to 170 Cuna Amerindians, 142 of whom were unrelated, and the drug and its dehydrometabolites were determined in the 0- to 12-hour urine samples. The log10 of the metabolic ratio was unimodally, but not normally, distributed and showed the following values: mean 0.21 ± 0.26, median 0.24, limits 0.73 and 0.76, skewness 1.00, and kurtosis 4.95. On the basis of these results, it can be concluded that there are no deficient metabolizers in the Cuna sample population studied. However, the similarity of the skewness found between the Cuna sample population studied and the extensive Canadian white group, as well as an inflection point at 6.3 U in the former's probit plot, suggests the existence of at least two subgroups congregating within the same single mode in the frequency distribution curve. The use of the inflection point is discussed thoroughly, concluding that although it does not allow exclusion of the existence of genotypically different subgroups, the limitations of the data do not permit its use to determine the number of heterozygotes and thus the existence of polymorphism. The possibility of an isozyme variant, consistent with the general genetic structure of Amerindians, as suggested by the coexistence of two subgroups within the unimodal curve, is entertained. (CLIN PHARmAcoL THER 1988;43:456-65.)es_ES
dc.description.sponsorshipUniversidad de Costa Rica. Instituto de Investigaciones en Salud.es_ES
dc.description.sponsorshipUniversidad de Panamáes_ES
dc.description.sponsorshipUniversidad de Torontoes_ES
dc.language.isoen_USes_ES
dc.sourceClinical Pharmacology & Therapeutics 43 (4): 456-465es_ES
dc.subjectdehydrometaboliteses_ES
dc.subjectpolymorphismes_ES
dc.subjectsparteine sulfatees_ES
dc.subjectLatin Americaes_ES
dc.subjectCuna Amerindian groupes_ES
dc.subjectamerindianses_ES
dc.titleThe oxidative metabolism of sparteine in the Cuna Amerindians of Panama: Absence of evidence for defient metabolizerses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1038/clpt.1988.58
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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