Association of serum pepsinogen with atrophic body gastritis in Costa Rica
Sierra Ramos, Rafaela
Une, Clas Allan
Ramírez Mayorga, Vanessa
González Lutz, María Isabel
Ramírez, José A.
de Mascarel, Antoine
Barahona García, Ricardo
Salas Aguilar, Rigoberto
Avendaño Alvarado, Gerardo
Ávalos Giugliarelli, Alessia
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Abstract Individuals with atrophic gastritis (AG), especially atrophic body gastritis (ABG), are at increased risk of developing gastric cancer. Serum concentrations of pepsinogens (PG) have been proposed as markers for ABG. The aim of this study was to determine the risk factors for AG and ABC and the potential of using serum PG concentrations to detect ABG in a dyspeptic population in Costa Rica, which is one of the countries with the highest incidence and mortality rates of gastric cancer in the world. Seven biopsy specimens, a fasting blood sample and a questionnaire concerning sociodemographic factors were obtained from 501 consecutive dyspeptic patients The sert.trn PG! level and the PCITPCII significantly lower in patients with ABG than in other groups (P<0.000). A cut-off point of 3.4 led to a sensitivity of 91.2% in identifying ABG, a negative predictive value of 98.1%, but a positive predictive value of only 11.2%. Helicobacter pylori were present in 93% of the patients and ail those with peptic ulcers were positive. AG was associated with increased age, lower body mass index, high alcohol intake and low fruit consumption. ABG was associated with age, alcohol consumption and PGI/PGII<3.4. In dyspeptic patients with a high prevalence of H. pylori infection, serum PG levels provide an assessment of ABG but it is necessary to introduce other serological and genetic markers in order to achieve a better specificity. Those markers could be serum antibodies to H. pylori-CagA, cytokine gene polymorphisms or others
Enlace externo al ítem10 1007/s10238-006-0098-3
Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 2006. Este artículo es privado debido a las políticas de la revista en la que el artículo fue publicado.