Listar por autor "055a9546-fb04-4c13-b42b-05b2e3d5bb62"
Mostrando ítems 1-8 de 8
-
A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu
Dos Santos, María Cristina; Gonçalves, Luís Roberto de Camargo; Fortes Dias, Consuelo L.; Cury, Yara; Gutiérrez, José María; Furtado, María de Fátima (1992)Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also ... -
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Gonçalves Dias, Renata; Sampaio Vessoni, Sandra Coccuzzo; Sant'Anna, Morena Brazil Martins; Cunha, Fernando Queiroz; Gutiérrez, José María; Lomonte, Bruno; Cury, Yara; Picolo, Gisele (2017-03-23)Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that ... -
Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms
Picolo, Gisele; Chacur, Marucia; Gutiérrez, José María; Teixeira, Catarina de Fátima; Cury, Yara (2002-10)Neutralization of hyperalgesia induced by Bothrops jararaca and B. asper venoms was studied in rats using bothropic antivenom produced at Instituto Butantan (AVIB, 1 ml neutralizes 5 mg B. jararaca venom) and polyvalent ... -
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants
Chacur, Marucia; Longo, I.; Picolo, Gisele; Gutiérrez, José María; Lomonte, Bruno; Guerra, J. L.; Teixeira, Catarina de Fátima; Cury, Yara (2003-05)The ability of Lys49 and Asp49 phospholipases A2 (PLA2), from Bothrops asper snake venom, to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of both toxins (5–20 μg/paw) ... -
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Franceschi, Aida; Chaves Mora, Fernando; León Montero, Guillermo; Cury, Yara; Ovadia, Michael; Gutiérrez, José María (2000-11)The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ... -
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
Chacur, Marucia; Picolo, Gisele; Gutiérrez, José María; Teixeira, Catarina de Fátima; Cury, Yara (2001-08)The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which ... -
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators
Chacur, Marucia; Gutiérrez, José María; Milligan, Erin D.; Wieseler Frank, Julie; Britto, Luiz R.G.; Maier, Steven F.; Watkins, Linda R.; Cury, Yara (2004-09)Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. ... -
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide
Chacur, Marucia; Milligan, Erin D.; Sloan, Evan M.; Wieseler Frank, Julie; Barrientos, Ruth M.; Martin, David; Poole, Stephen; Lomonte, Bruno; Gutiérrez, José María; Maier, Steven F.; Cury, Yara; Watkins, Linda R. (2004-03)Snakebites constitute a serious public health problem in Central and South America, where species of the lancehead pit vipers (genus Bothrops) cause the majority of accidents. Bothrops envenomations are very painful, and ...