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dc.creatorCornet Gomez, Alberto
dc.creatorRetana Moreira, Lissette
dc.creatorKronenberger, Thales
dc.creatorOsuna Carrillo de Albornoz, Antonio
dc.date.accessioned2023-08-04T19:44:01Z
dc.date.available2023-08-04T19:44:01Z
dc.date.issued2023
dc.identifier.citationhttps://www.nature.com/articles/s41598-023-34820-6es_ES
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10669/89789
dc.description.abstractChagas disease is caused by the protozoan parasite Trypanosoma cruzi. The disease has an acute and a chronic phase in which approximately 30% of the chronic patients suffer from heart disease and/or gastrointestinal symptoms. The pathogenesis of the disease is multifactorial and involves the virulence of the strains, immunological factors and extracellular vesicles (EV) shed by the parasite which participate in cell–cell communication and evasion of the immune response. In this work, we present a transcriptomic analysis of cells stimulated with EV of the trypomastigote stage of T. cruzi. Results after EV-cell incubation revealed 322 differentially expressed genes (168 were upregulated and 154 were downregulated). In this regard, the overexpression of genes related to ubiquitin-related processes (Ube2C, SUMO1 and SUMO2) is highlighted. Moreover, the expression of Rho-GTPases (RhoA, Rac1 and Cdc42) after the interaction was analyzed, revealing a downregulation of the analyzed genes after 4 h of interaction. Finally, a protective role of EV over apoptosis is suggested, as relative values of cells in early and late apoptosis were significantly lower in EV-treated cells, which also showed increased CSNK1G1 expression. These results contribute to a better understanding of the EV-cell interaction and support the role of EV as virulence factors.es_ES
dc.language.isoenges_ES
dc.sourceScientific Reports, vol.13 (7618).es_ES
dc.subjectCELLSes_ES
dc.subjectINFECTIOUS DISEASESes_ES
dc.subjectDISEASESes_ES
dc.subjectPARASITOLOGYes_ES
dc.titleExtracellular vesicles of trypomastigotes of Trypanosoma cruzi induce changes in ubiquitin-related processes, cell-signaling pathways and apoptosises_ES
dc.typeartículo originales_ES
dc.identifier.doi10.1038/s41598-023-34820-6
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES


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