A facile method for the preparation of bishomopropargylic alcohols from acyl chlorides
artículo científico
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Date
2014Author
Vásquez Céspedes, Suhelen
Cabezas Pizarro, Jorge A.
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Controlled dilithiation of propargyl bromide with two equivalents of n-butyllithium, in the presence of
TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts
efficiently with acid chlorides to produce bishomopropargylic alcohols in a single step route and with
high regioselectivity and moderate yields.
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10.1016/j.tetlet.2014.01.144Collections
- Química [316]