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dc.creatorKreimerman, Ingrid
dc.creatorMora Ramírez, Erick
dc.creatorReyes, Laura
dc.creatorBardiès, Manuel
dc.creatorSavio Quevedo, Eduardo
dc.creatorEngler, Henry
dc.description.abstractAbstract: Background: The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sul forhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo. Objective: The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to esti mate human radiation dosimetry based on preclinical studies. Methods: Radiation dosimetry studies were conducted based on biokinetic data obtained from a mouse model. A single-dose toxicity study was carried out. The toxicological limit chosen was <100 µg, and allometric scaling with a safety factor of 100 for unlabelled SRF101 was selected. Results: The absorbed and effective dose estimated using OLINDA/EXM V2.0 for male and female dosimetric models presented the same tendency. The highest total absorbed dose values were for dif ferent sections of the intestines. The mean effective dose was 4.03 x10-3 mSv/MBq and 5.08 x10-3 mSv/MBq for the male and female dosimetric models, respectively, using tissue-weighting factors from ICRP-89. The toxicity study detected no changes in the organ or whole-body weight, food consumption, haema tologic or clinical chemistry parameters. Moreover, lesions or abnormalities were not found during the histopathological examination. Conclusion: The toxicological evaluation of SRF101 verified the biosafety of the radiotracer for hu man administration. The dosimetry calculations revealed that the radiation-associated risk of [ 18F]SRF101 would be of the same order as other 18F radiopharmaceuticals used in clinical applica tions. These study findings confirm that the novel radiotracer would be safe for use in human PET imaging.es_ES
dc.rightsCC0 1.0 Universal*
dc.sourceCurrent Radiopharmaceuticals, vol.12(1): pp. 40-48es_ES
dc.subjectPreclinical evaluationes_ES
dc.subjectPET radiotracerses_ES
dc.subjectTissue-weighting factorses_ES
dc.titleDosimetry and Toxicity Studies of the Novel Sulfonamide Derivative of Sulforhodamine 101([18f]srf101) at a Preclinical Leveles_ES
dc.typeartículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Ciencias Atómicas Nucleares y Moleculares (CICANUM)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Físicaes_ES

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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal