Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

Silva Carvalho, Rosimeire; Gaspar, Matheus Z.; Quadros, Luiz H. B.; Lobo, Luís G. G.; Giuffrida, Rogério; Santarém, Cecília L.; Silva, Elisangela O.; Gerez, Juliana Rubira; Silva, Nelson J.; Hyslop, Stephen; Lomonte, Bruno; Floriano, Rafael Stuani

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2022_Antivenenos_Toxicon_Silva_Micrurus_dumerilii_Varespladib.pdf (715.4Kb)

Fecha

2022

Autor

Silva Carvalho, Rosimeire

Gaspar, Matheus Z.

Quadros, Luiz H. B.

Lobo, Luís G. G.

Giuffrida, Rogério

Santarém, Cecília L.

Silva, Elisangela O.

Gerez, Juliana Rubira

Silva, Nelson J.

Hyslop, Stephen

Lomonte, Bruno

Floriano, Rafael Stuani

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Resumen

In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations