Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

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Date
2022
Author
Silva Carvalho, Rosimeire
Gaspar, Matheus Z.
Quadros, Luiz H. B.
Lobo, Luís G. G.
Giuffrida, Rogério
Santarém, Cecília L.
Silva, Elisangela O.
Gerez, Juliana Rubira
Silva, Nelson J.
Hyslop, Stephen
Lomonte, Bruno
Floriano, Rafael Stuani
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Abstract
In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
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https://hdl.handle.net/10669/88017
External link to the item
doi.org/10.1016/j.toxicon.2022.04.014
https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub
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