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dc.creatorHernández Altamirano, Josselin A.
dc.creatorSalazar Valenzuela, David
dc.creatorMedina Villamizar, Evencio J.
dc.creatorQuirola, Diego R.
dc.creatorPatel, Ketan
dc.creatorVaiyapuri, Sakthivel
dc.creatorLomonte, Bruno
dc.creatorAlmeida, José R.
dc.description.abstractMicrurus is a medically relevant genus of venomous snakes composed of 85 species. Bites caused by coral snakes are rare, but they are usually associated with very severe and life-threatening clinical manifestations. Ecuador is a highly biodiverse country with a complex natural environment, which is home to approximately 20% of identified Micrurus species. Additionally, it is on the list of Latin American countries with the highest number of snakebites. However, there is no local antivenom available against the Ecuadorian snake venoms, and the biochemistry of these venoms has been poorly explored. Only a limited number of samples collected in the country from the Viperidae family were recently characterised. Therefore, this study addressed the compositional patterns of two coral snake venoms from Ecuador, M. helleri and M. mipartitus, using venomics strategies, integrating sample fractionation, gel electrophoresis, and mass spectrometry. Chromatographic and electrophoretic profiles of these snake venoms revealed interspecific variability, which was ascertained by mass spectrometry. The two venoms followed the recently recognised dichotomic toxin expression trends displayed by Micrurus species: M. helleri venom contains a high proportion (72%) of phospholipase A2, whereas M. mipartitus venom is dominated by three-finger toxins (63%). A few additional protein families were also detected in these venoms. Overall, these results provide the first comprehensive views on the composition of two Ecuadorian coral snake venoms and expand the knowledge of Micrurus venom phenotypes. These findings open novel perspectives to further research the functional aspects of these biological cocktails of PLA2s and 3FTxs and stress the need for the preclinical evaluation of the currently used antivenoms for therapeutic purposes in Ecuadores_ES
dc.rightsCC0 1.0 Universal*
dc.sourceInternational Journal of Molecular Sciences, vol.23(23), pp.14686.es_ES
dc.subjectCoral snakees_ES
dc.subjectMass spectrometryes_ES
dc.subjectPhospholipase A2es_ES
dc.subjectThree-finger toxinses_ES
dc.subjectSnake venomes_ES
dc.titleFirst insights into the venom composition of two Ecuadorian coral snakeses_ES
dc.typeartículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES

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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal