Synthesis and Antibacterial Activity of Aromatic Homopropargyl Alcohols
Umaña, Christian A.
Arias Echandi, María Laura
Cabezas Pizarro, Jorge A.
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Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols thus prepared, against Gram (+) and Gram (−) bacteria was tested. This activity varies depending upon substitution on the homopropargyl alcohol unit. Apparently, the benzene ring and the free hydroxyl group (or its alcoxide) are needed, in the homopropar- gyl alcohol unit, to be biologically active.
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