Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols

dc.creator	Umaña, Christian A.
dc.creator	Cabezas Pizarro, Jorge A.
dc.date.accessioned	2023-01-03T16:38:52Z
dc.date.available	2023-01-03T16:38:52Z
dc.date.issued	2017
dc.identifier.citation	https://pubs.acs.org/doi/10.1021/acs.joc.7b01529	es_ES
dc.identifier.issn	0022-3263
dc.identifier.uri	https://hdl.handle.net/10669/87985
dc.description.abstract	Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generated the equivalent of 1,3- dilithiopropyne, which adds regiospecifically to aldehydes and ketones to produce homopropargyl alcohols. The lithium acetylide intermediate formed in this protocol can be further reacted with aromatic and vinyl halides, under palladium catalysis, to produce 4-substituted homopropargyl alcohols and 5-en-3-yn-1-ols, respectively, in one-pot with good overall yields.	es_ES
dc.language.iso	eng	es_ES
dc.source	J. Org. Chem. 2017, 82, 18, 9505–9514	es_ES
dc.subject	Alcohols	es_ES
dc.subject	Allenes	es_ES
dc.subject	Aromatic compounds	es_ES
dc.subject	Hydrocarbons	es_ES
dc.subject	Palladium	es_ES
dc.title	Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols	es_ES
dc.type	artículo científico	es_ES
dc.identifier.doi	10.1021/acs.joc.7b01529
dc.description.procedence	UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química	es_ES