Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols
artículo científico
Fecha
2017Autor
Umaña, Christian A.
Cabezas Pizarro, Jorge A.
Metadatos
Mostrar el registro completo del ítemResumen
Sequential treatment of 2,3-dichloropropene
with magnesium and n-BuLi generated the equivalent of 1,3-
dilithiopropyne, which adds regiospecifically to aldehydes and
ketones to produce homopropargyl alcohols. The lithium
acetylide intermediate formed in this protocol can be further
reacted with aromatic and vinyl halides, under palladium
catalysis, to produce 4-substituted homopropargyl alcohols and
5-en-3-yn-1-ols, respectively, in one-pot with good overall
yields.
External link to the item
10.1021/acs.joc.7b01529Colecciones
- Química [316]