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dc.creatorKayal, Gunjan
dc.creatorChauvin, Maxime
dc.creatorMora Ramírez, Erick
dc.creatorClayton, Naomi
dc.creatorVergara Gil, Alex
dc.creatorTran Gia, Johannes
dc.creatorLassmann, Michael
dc.creatorCalvert, Nicholas
dc.creatorTipping, Jill
dc.creatorStruelens, Lara
dc.creatorBardiès, Manuel
dc.description.abstractPurpose Monte Carlo modelling of SPECT imaging in Molecular Radiotherapy can improve activity quantification. Until now, SPECT modelling with GATE only considered circular orbit (CO) acquisitions. This cannot reproduce auto-contour acquisitions, where the detector head moves close to the patient to improve image resolution. The aim of this work is to develop and validate an auto-contouring step-and-shoot acquisition mode for GATE SPECT modelling. Methods 177Lu and 131I SPECT experimental acquisitions performed on a Siemens Symbia T2 and GE Discovery 670 gamma camera, respectively, were modelled. SPECT projections were obtained for a cylindrical Jaszczak phantom and a lung and spine phantom. Detector head parameters (radial positions and acquisition angles) were extracted from the experimental projections to model the non-circular orbit (NCO) detector motion. The gamma camera model was validated against the experimental projections obtained with the cylindrical Jaszczak (177Lu) and lung and spine phantom (131I). Then, 177Lu and 131I CO and NCO SPECT projections were simulated to validate the impact of explicit NCO modelling on simulated projections. Results Experimental and simulated SPECT images were compared using the gamma index, and were in good agreement with gamma index passing rate (GIPR) and gammaavg of 96.27%, 0.242 (177Lu) and 92.89%, 0.36 (131I). Then, simulated 177Lu and 131I CO and NCO SPECT projections were compared. The GIPR, gammaavg between the two gamma camera motions was 99.85%, 0.108 for 177Lu and 75.58%, 0.6 for 131I. Conclusion This work thereby justifies the need for auto-contouring modelling for isotopes with high septal penetration.es_ES
dc.description.sponsorshipHorizon Europe/[15HLT06]/EU/Union Europeaes_ES
dc.description.sponsorshipHorizon Europe/[755523]/EU/Union Europeaes_ES
dc.description.sponsorshipHorizon Europe/[75576]/EU/Union Europeaes_ES
dc.rightsCC0 1.0 Universal*
dc.sourcePhysica Medica, vol.96, pp.101-113.es_ES
dc.subjectGATE Monte Carlo modellinges_ES
dc.subjectSPECT imaginges_ES
dc.titleModelling SPECT auto-contouring acquisitions for 177Lu & 131I molecular radiotherapy using new developments in Geant4/GATEes_ES
dc.typeartículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Ciencias Atómicas Nucleares y Moleculares (CICANUM)es_ES

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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal