A new method for the preparation of 1,3-dilithiopropyne: an efficient synthesis of homopropargyl alcohols
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Date
2001Author
Cabezas Pizarro, Jorge A.
Pereira, Albán R.
Amey, Adam R.
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Controlled dilithiation of propargyl bromide with two equivalents of n-butyllithium, in the presence of TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts efficiently with aldehydes and ketones to produce homopropargyl alcohols in a single step route and in high yields.
Controlled dilithiation of propargyl bromide with n-BuLi, in the presence of TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts efficiently with aldehydes and ketones to produce homopropargyl alcohols in a single step route in high yields.
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10.1016/S0040-4039(01)01429-0Collections
- Química [341]