Synthesis and antibacterial activity of Jacaranone and ester side chain analogs
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Date
1991Author
Cabezas Pizarro, Jorge A.
Cicció Alberti, José Francisco
Hidalgo, G.
Echandi, Guillermo
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Jacaranone and several novel ester side chain derivatives have been synthesized and tested for antibacterial activity. The syntheses of these compounds involved the convenient lithium enolate ester adition to p-benzoquinone. The results indicated an increase in the activity against Gram-positive bacteria as a consequence of increased lipophylicity in the ester side chains.
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